FLUTAMIDE TREATMENT OF PREMENSTRUAL DYSPHORIC DISORDER

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的主要目的是确定使用雄激素受体拮抗剂氟他胺阻断雄激素受体是否会缓解经前焦虑症的症状。将进行一项安慰剂对照、平行设计的先导研究。受试者将被招募，这将允许检测氟他胺治疗的大效应，并提供数据以估计较小的效应大小，用于更大规模的研究设计，如果有指示的话。氟他胺治疗的耐受性也将通过比较氟他胺治疗和安慰剂治疗的副作用来评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this study is to determine whether androgen receptor blockade using the androgen receptor antagonist flutamide will relieve symptoms of premenstrual dysphoric disorder. A placebo controlled, parallel design pilot study will be conducted. 64 subjects will be recruited, which will allow detection of a large effect of flutamide treatment, and provide data to estimate smaller effect sizes for use in design of a larger-scale study, if indicated. Tolerability of flutamide treatment will also be estimated by comparison of side effects between flutamide and placebo treatment.