EFFECT OF PREGNANCY ON ANXIETY

怀孕对焦虑的影响

• 批准号: 7604209
• 负责人: MARGARET ALTEMUS
• 金额: $ 0.04万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604209
• 关键词: Anxiety; Anxiety Disorders; Applications Grants; Arousal; Blood Pressure; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Grant; Institution; Lactation; Pilot Projects; Pregnancy; Rate; Research; Research Design; Research Personnel; Resources; Severities; Sinus Arrhythmia; Source; Symptoms; United States National Institutes of Health; Weaning; Woman; respiratory

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study is a pilot study, designed to obtain additional pilot data regarding recruitment and retention rates, effects of pregnancy on axiety, and effects of weaning on anxiety, needed for resubmission of an NIH grant application. Aim 1: To evaluate potential differential effects of pregnancy on the course and severity of anxiety symptoms in 50 women with PD, OCD or GAD. Hypothesis 1) - In subjects with subthreshold or full criteria PD, OCD, or GAD at study entry, OCD and GAD symptoms will increase during pregnancy and PD symtoms will decrease. Aim 2: To determine the extent to which lactation and weaning modulate autonomic arousal and anxiety. Hypothesis 2a) - Rapid weaning will be associated with an increase in autonomic arousal. Autonomic arousal will be represented by reductions in respiratory sinus arrhythmia (vagal tone) and vagal brake, and as an increase in systolic blood pressure. Hypothesis 2b) - Rapid weaning will be associated with worsening anxiety symptoms in women with anxiety disorders at baseline.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议的研究是一项试点研究，旨在获得有关招募和保留率、怀孕对焦虑的影响以及断奶对焦虑的影响的额外试点数据，这些数据是重新提交 NIH 拨款申请所需的。 目标 1：评估妊娠对 50 名患有 PD、OCD 或 GAD 的女性焦虑症状的过程和严重程度的潜在不同影响。假设 1) - 在研究开始时患有阈下或完全标准 PD、OCD 或 GAD 的受试者中，OCD 和 GAD 症状在怀孕期间会增加，而 PD 症状会减少。 目标 2：确定哺乳和断奶调节自主神经唤醒和焦虑的程度。 假设 2a) - 快速断奶与自主神经兴奋的增加有关。 自主神经唤醒表现为呼吸性窦性心律失常（迷走神经张力）和迷走神经制动的减少以及收缩压的增加。 假设 2b) - 快速断奶与基线患有焦虑症的女性焦虑症状恶化有关。