EFFECT OF PREGNANCY ON ANXIETY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。拟议的研究是一项试点研究，旨在获得关于招聘和保留率，怀孕对焦虑的影响以及断奶对焦虑的影响的额外试点数据，这些数据需要重新提交NIH资助申请。目的1：评估怀孕对50名PD、OCD或GAD女性焦虑症状的病程和严重程度的潜在差异影响。假设1)-在研究开始时患有亚阈值或完全标准PD、OCD或GAD的受试者中，OCD和GAD症状在怀孕期间会加重，PD症状会减轻。目的2：确定哺乳和断奶调节自主神经觉醒和焦虑的程度。假设2a) -快速断奶与自主神经觉醒的增加有关。自主神经觉醒表现为呼吸性窦性心律失常（迷走神经张力）和迷走神经制动的减少，以及收缩压的升高。假设2b) -在基线时患有焦虑症的妇女，快速断奶与焦虑症状恶化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study is a pilot study, designed to obtain additional pilot data regarding recruitment and retention rates, effects of pregnancy on axiety, and effects of weaning on anxiety, needed for resubmission of an NIH grant application. Aim 1: To evaluate potential differential effects of pregnancy on the course and severity of anxiety symptoms in 50 women with PD, OCD or GAD. Hypothesis 1) - In subjects with subthreshold or full criteria PD, OCD, or GAD at study entry, OCD and GAD symptoms will increase during pregnancy and PD symtoms will decrease. Aim 2: To determine the extent to which lactation and weaning modulate autonomic arousal and anxiety. Hypothesis 2a) - Rapid weaning will be associated with an increase in autonomic arousal. Autonomic arousal will be represented by reductions in respiratory sinus arrhythmia (vagal tone) and vagal brake, and as an increase in systolic blood pressure. Hypothesis 2b) - Rapid weaning will be associated with worsening anxiety symptoms in women with anxiety disorders at baseline.