EFFECT OF CATECHOLAMINES ON EMOTIONAL MEMORY

儿茶酚胺对情绪记忆的影响

• 批准号: 7378377
• 负责人: MARGARET ALTEMUS
• 金额: $ 8.51万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378377
• 关键词: EFFECT; CATECHOLAMINES; EMOTIONAL; MEMORY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Based on studies in rodents, we hypothesize that when an emotional memory is recalled, it undergoes reconsolidation and that reconsolidation can be impaired by blockade of beta-adrenergic receptor stimulation. The primary aim of this study is to determine whether acute administration of the beta-adrenergic blocker propranolol impairs reconsolidation of conditioned fear. 80 subjects will undergo fear conditioning using visual cues paired with a mild wrist shock, and conditioning will be assessed using galvanic skin response. Subjects will receive either propranolol or placebo on the following day, immediately after a brief presentation of the visual cues which had previously been paired with a shock. A third group of subject will receive propranolol without cue re-exposure. On the following day, extinction of the fear response will be compared among groups.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。基于对啮齿动物的研究，我们假设，当回忆起情绪记忆时，它会经历重新巩固，并且重新巩固可以通过阻断β-肾上腺素能受体刺激而受损。 本研究的主要目的是确定急性给予β-肾上腺素能受体阻滞剂普萘洛尔是否会损害条件性恐惧的再巩固。80名受试者将使用视觉提示与轻度手腕电击进行恐惧条件反射，并将使用皮肤电反应评估条件反射。受试者将在第二天接受普萘洛尔或安慰剂，在短暂呈现之前与电击配对的视觉提示后立即接受。第三组受试者将接受普萘洛尔，不进行提示再暴露。 第二天，将比较各组之间恐惧反应的消退。