PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFECTED

垂直 HIV 感染者形态和代谢异常的患病率

• 批准号: 7368215
• 负责人: JAMES HOMANS
• 金额: $ 1.51万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368215
• 关键词: PREVALENCE; MORPHOLOGIC; METABOLIC; ABNORMALITIES; VERTICALLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PACTG P1045 is a cross-sectional study designed to evaluated the prevalence of morphologic and metabolic abnormalities in vertically HIV-infected children and youth and uninfected children and youth. This study will (1) comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density, (2) evaluate whether exposure to protease inhibitors (PIs) is correlated with metabolic and morphologic abnormalities among HIV-infected youth, and (3) compare the prevalence of abnormalities in this population according to Tanner Stage. These data are critical for designing intervention trials and studies designed to determine pathophysiologic mechanisms.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。PACTG P1045是一项横断面研究，旨在评估垂直HIV感染儿童和青少年与未感染儿童和青少年的形态学和代谢异常的患病率。本研究将（1）全面评价糖代谢、血脂水平、身体成分、脂肪沉积和分布以及骨密度异常的患病率，（2）评价蛋白酶抑制剂（PI）暴露是否与HIV感染青年的代谢和形态异常相关，（3）根据坦纳分期比较该人群的异常患病率。这些数据对于设计干预试验和旨在确定病理生理机制的研究至关重要。