PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFEC

垂直 HIV 感染者形态和代谢异常的患病率

• 批准号: 7376075
• 负责人: MARGARET A KELLER
• 金额: $ 1.03万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376075
• 关键词: PREVALENCE; MORPHOLOGIC; METABOLIC; ABNORMALITIES; VERTICALLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to look at glucose metabolism (how the body breaks down blood sugar), the amounts of lipids (fats), proteins, and other substances in the blood, the amount of body fat and fat distribution, and how dense (solid) bones are in: a) HIV-infected children compared to HIV-uninfected children; b) HIV-infected children and uninfected children at different stages of sexual development; c) HIV infected children taking a class of anti-HIV drugs called protease inhibitors (PIs) compared to HIV-infected children not taking PIs. About 450 children will take part in this study, 7-14 from the Harbor-UCLA site. The child will have two special x-rays done. These x-rays are called dual energy x-ray absorptiometry (DEXA) scans. One of the x-rays will scan the whole body and the other x-ray will scan just the spine and hip. The child's height and weight will be measured. The distance around the child's waist, hips, arm and thigh will be measured using a measuring tape. Folds of skin will be measured at the child's arm, shoulder, stomach, hip and thigh using calipers, a harmless device that looks like pliers. The child will be asked to answer some questions about changs in his/her body image and appearance. The child will be asked some questions about the kinds of food the child eats normally and how often the child eats. The child will also be asked specific questions about the food the child ate the day before he/she came to the clinic. Routine and special blood tests will be drawn. The study will be from 1 visit (3 hrs) to 3 visits (each 1-2 hrs) within 30 days.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这项研究的目的是观察葡萄糖代谢（身体如何分解血糖），血液中脂质（脂肪）、蛋白质和其他物质的含量，身体脂肪的含量和脂肪分布，以及骨骼的密度（固体）：a）感染艾滋病毒的儿童与未感染艾滋病毒的儿童的比较; B）感染艾滋病毒的儿童和未感染艾滋病毒的儿童在不同的性发育阶段; c）与未服用蛋白酶抑制剂（PI）的HIV感染儿童相比，服用一类抗HIV药物的HIV感染儿童。大约450名儿童将参加这项研究，7-14名来自加州大学洛杉矶分校的港口。 这名儿童将接受两次特殊的X光检查。这些X射线被称为双能X射线吸收测定法（DEXA）扫描。其中一个X光片将扫描整个身体，另一个X光片将只扫描脊柱和臀部。 将测量孩子的身高和体重。将使用卷尺测量孩子腰部、臀部、手臂和大腿周围的距离。皮肤褶皱将在孩子的手臂，肩膀，腹部，臀部和大腿使用卡尺，一个无害的设备，看起来像钳子测量。 孩子将被要求回答一些关于他/她的身体形象和外观变化的问题。 孩子会被问到一些关于孩子通常吃的食物种类和孩子吃的频率的问题。还将询问儿童关于他/她来诊所前一天吃的食物的具体问题。将进行常规和特殊血液检查。研究将在30天内进行1次访视（3小时）至3次访视（每次1-2小时）。