PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFEC

垂直 HIV 感染者形态和代谢异常的患病率

• 批准号: 7376075
• 负责人: MARGARET A KELLER
• 金额: $ 1.03万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376075
• 关键词: PREVALENCE; MORPHOLOGIC; METABOLIC; ABNORMALITIES; VERTICALLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to look at glucose metabolism (how the body breaks down blood sugar), the amounts of lipids (fats), proteins, and other substances in the blood, the amount of body fat and fat distribution, and how dense (solid) bones are in: a) HIV-infected children compared to HIV-uninfected children; b) HIV-infected children and uninfected children at different stages of sexual development; c) HIV infected children taking a class of anti-HIV drugs called protease inhibitors (PIs) compared to HIV-infected children not taking PIs. About 450 children will take part in this study, 7-14 from the Harbor-UCLA site. The child will have two special x-rays done. These x-rays are called dual energy x-ray absorptiometry (DEXA) scans. One of the x-rays will scan the whole body and the other x-ray will scan just the spine and hip. The child's height and weight will be measured. The distance around the child's waist, hips, arm and thigh will be measured using a measuring tape. Folds of skin will be measured at the child's arm, shoulder, stomach, hip and thigh using calipers, a harmless device that looks like pliers. The child will be asked to answer some questions about changs in his/her body image and appearance. The child will be asked some questions about the kinds of food the child eats normally and how often the child eats. The child will also be asked specific questions about the food the child ate the day before he/she came to the clinic. Routine and special blood tests will be drawn. The study will be from 1 visit (3 hrs) to 3 visits (each 1-2 hrs) within 30 days.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。本研究的目的是观察以下部位的葡萄糖代谢（身体如何分解血糖）、血液中脂质（脂肪）、蛋白质和其他物质的含量、体内脂肪量和脂肪分布以及骨骼的密度（固体）： a) 与未感染 HIV 的儿童相比，HIV 感染儿童； b) 性发育不同阶段的艾滋病毒感染儿童和未感染儿童； c) 服用一类称为蛋白酶抑制剂 (PI) 的抗 HIV 药物的 HIV 感染儿童与未服用 PI 的 HIV 感染儿童进行比较。大约 450 名儿童将参加这项研究，其中 7 至 14 名来自 Harbour-UCLA 基地。 孩子将接受两次特殊的 X 光检查。这些 X 射线称为双能 X 射线吸收测定法 (DEXA) 扫描。其中一张 X 射线将扫描整个身体，另一张 X 射线将仅扫描脊柱和臀部。 将测量孩子的身高和体重。将使用卷尺测量孩子腰部、臀部、手臂和大腿周围的距离。将使用卡尺（一种看起来像钳子的无害设备）测量孩子手臂、肩膀、腹部、臀部和大腿的皮肤褶皱。 孩子将被要求回答一些有关他/她的身体形象和外表变化的问题。 孩子会被问到一些关于孩子正常吃的食物种类以及孩子吃的频率的问题。还将向孩子询问有关孩子来诊所前一天所吃食物的具体问题。将进行常规和特殊血液检查。该研究将在 30 天内从 1 次访视（3 小时）到 3 次访视（每次 1-2 小时）。