PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN HIV INFECTED

HIV 感染者形态和代谢异常的患病率

• 批准号: 7368216
• 负责人: JAMES HOMANS
• 金额: $ 0.61万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368216
• 关键词: PREVALENCE; MORPHOLOGIC; METABOLIC; ABNORMALITIES; HIV

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Adolescent Trials Network (ATN) protocol 021 is a cross-sectional survey, designed to evaluate the prevalence and severity of morphologic and metabolic abnormalities in HIV-infected female youth and to assess the drug and non-drug factors related to these abnormalities. This study will assess whether there exist significant differences in glucose metabolism, lipids, lactate, body composition and bone density between HIV-infected and uninfected young women. Furthermore, this study will evaluate whether exposure to specific classes of antiretroviral (ARV) medications is associated with the metabolic and morphologic abnormalities among HIV-infected individuals in different ways. The study involves a one-time collection of medical history data, laboratory specimens, and physical assessments. This study will elucidate the need for further in-depth study to understand the pathophysiological effects of protease inhibitor (PI)- and non-nucleoside analogue reverse transcriptase inhibitor (NNRTI)-based therapies in young females.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。青少年试验网络（ATN）协议021是一项横断面调查，旨在评估艾滋病毒感染的女性青年的形态和代谢异常的患病率和严重程度，并评估与这些异常相关的药物和非药物因素。本研究将评估是否存在显着差异，在糖代谢，脂质，乳酸，身体成分和骨密度之间的HIV感染和未感染的年轻女性。此外，本研究将评估暴露于特定类别的抗逆转录病毒（ARV）药物是否与HIV感染者的代谢和形态异常以不同方式相关。本研究涉及一次性收集病史数据、实验室标本和体格评估。本研究将阐明进一步深入研究的必要性，以了解蛋白酶抑制剂（PI）和非核苷类似物逆转录酶抑制剂（NNRTI）为基础的治疗在年轻女性中的病理生理学作用。