ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项非随机化的自然病史非治疗研究，总共将在美国和加拿大的大约50个地点招募800名受试者，其中包括200名正常对照组、400名轻度认知障碍患者和200名轻度阿尔茨海默病(AD)受试者，以进行纵向跟踪。这项研究旨在考察成像研究和生物标记物测试，以及对记忆、思维和日常功能的测量，在未来进行的研究中的用处，这些研究将侧重于阿尔茨海默病的早期识别和治疗。这项研究的目的是为这类未来的研究提供存储的数据。对于这个项目，我们将招募总共20名受试者，如下所列：这项研究将观察三组不同的志愿者：1)正常对照组：志愿者没有明显的记忆问题，将进行为期36个月的研究。这一组中的四名受试者将被招募2)轻度认知障碍(MCI)组：通过一系列记忆和认知测试的分数来确定有轻度记忆问题的志愿者(在本研究中被称为“轻度认知障碍”-MCI)，将进行为期36个月的研究。8名受试者将被招募为阿尔茨海默氏症组：患有轻度阿尔茨海默氏症的志愿者，将进行为期24个月的研究。将招募四名受试者，并有四名学习伙伴陪同。所有参与者必须有一个人(配偶、朋友或亲戚)，称为“研究伙伴”，此人愿意：陪同参与者进行所有研究访问，并传达参与者在研究期间健康状况的变化。所有受试者都将每年接受神经心理测试和1.5特斯拉脑部核磁共振检查。一组受试者(N=4)将接受两次腰椎穿刺术(基线和一年)，另一组受试者将在随后的检查中接受3T磁共振扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a non-randomized natural history non-treatment study in which a total of 800 subjects including 200 normal controls, 400 individuals with mild cognitive impairment, and 200 subjects with mild Alzheimer's Disease (AD) will be recruited at approximately fifty sites in the United States and Canada for longitudinal follow up. This research study is designed to look at the usefulness of imaging studies and biomarker tests, together with measurements of memory, thinking and daily functioning, in the future conduct of studies that will focus on the identification and treatment of Alzheimer's disease at an early stage. This study aims to produce data to be stored for these kinds of future research studies. For this project we will be recruiting at total of 20 subjects as listed below: This study will look at three different groups of volunteers: 1) Normal Control group: Volunteers with no apparent memory problems that will be studied for 36 months. Four subjects from this group will be recruited 2) Mild Cognitive Impairment (MCI) Group: volunteers with mild memory problems as determined by a series of scores on memory and cognitive tests, (referred to in this study as "mild cognitive impairment" - MCI) that will be studied for 36 months. Eight subjects will be recruited 3) Alzheimer's disease group: volunteers with mild Alzheimer's disease that will be studied for 24 months. Four subjects will be recruited, and four study partners to accompany them. All Participants must have an individual (spouse, friend, or relative), called a "study partner," who is willing to: accompany participants to all of the study visits and communicate changes in participant's health status over the period of this study. All subjects will have neuropsychological testing annually and a 1.5 Tesla brain MRI. A subset of subjects (N = 4) will receive 2 lumbar punctures (baseline and one year) and another subset of subjects will get a 3T MRI scan at a subsequent visit.