NUTRITION SUPPORT IN PEDIATRIC STEM CELL TRANSPLANTATION - A RCT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims/Objectives: Children undergoing stem cell transplantation often require parenteral nutrition to provide adequate calories and protein due to severe mucositis and other gastrointestinal complication of the preparative regimen (1). Accurate provision of energy may reduce complications related to overfeeding (2) or underfeeding (3). we hypothesize that changes in body composition during SCT affect REE, and that the standard approach to nutritional management of these patients may lead to overfeeding. We propose a prospective, randomized controlled trial to compare the nutrional effects of the standard method of nutritional support with an approach in which energy intake is provided to exactly meet resting energy expenditure as measured by indirect calorimetry.