Patient-oriented Research in Pediatric Diarrheal Diseases

描述（由申请人提供）：胃肠道疾病导致儿童显着发病和死亡。在发展中国家，感染性腹泻，包括与艾滋病毒/艾滋病相关的感染性腹泻，是导致死亡的主要原因。在工业化国家，患有短肠综合症的儿童患有慢性腹泻，需要肠外和肠内营养治疗。此修订后的申请要求克里斯托弗·杜根（Christopher Duggan）（医学博士、公共卫生硕士）获得以患者为导向的研究（K24）中的职业生涯中期研究员奖。杜根博士的总体研究目标是改善腹泻疾病的临床结果。他在营养、胃肠病学和国际健康领域的资助研究方面有着高生产力的记录。杜根博士拥有良好的指导记录以及与初级研究人员合作的绝佳机会。他是波士顿儿童医院 (CHB) 胃肠病学和营养科的临床研究主任、CHB 临床研究项目的教员、NIH 支持的哈佛消化疾病研究中心的成员、哈佛医学院儿科副教授和哈佛公共卫生学院营养学副教授。接受两个 T32 培训计划支持的学员可以作为学员。 K24 奖项中拟议的研究扩展了 Duggan 博士正在进行的研究，包括 NICHD 支持的 R01 拨款，旨在评估微量营养素补充剂对有腹泻风险的坦桑尼亚儿童的功效。他和同事将进行一项随机临床试验： 1. 确定补充锌或微量营养素是否对预防坦桑尼亚儿童胃肠道感染具有肠道病原体物种特异性作用； 2. 确定与不含锌的微量营养素补充剂相比，常规锌补充剂是否会降低坦桑尼亚儿童的铁状况指标。该应用程序提供了一个非常成功的研究人员在一个支持性和智力丰富的环境中的结合。需要获得这一职业生涯中期研究员奖，以保护杜根博士有时间指导刚起步的研究人员进行以患者为导向的营养研究，并扩大他在腹泻疾病方面的研究。） 公共卫生相关性：腹泻病是全世界儿童死亡和发病的重要原因。此次 K24 职业发展奖申请将评估补锌是否对降低坦桑尼亚儿童腹泻发病率具有物种特异性作用，并将支持申请人的指导能力，以培养营养、腹泻和全球健康领域年轻研究人员的职业生涯。

DESCRIPTION (provided by applicant): Diseases of the gastrointestinal tract cause significant morbidity and mortality among children. In developing countries, episodes of infectious diarrhea, including those associated with HIV/AIDS, are major causes of death. In industrialized countries, children with short bowel syndrome suffer from chronic diarrhea requiring treatment with parenteral and enteral nutrition. This revised application requests a mid-career investigator award in patient-oriented research (K24) for Christopher Duggan, MD, MPH. Dr. Duggan's overall research goal is to improve clinical outcomes in diarrheal diseases. He has a record of high productivity in funded research in the fields of nutrition, gastroenterology, and international health. Dr. Duggan has a sound track record of mentoring and excellent opportunities to work with junior investigators. He is Director of Clinical Research in the Division of Gastroenterology and Nutrition at Children's Hospital, Boston (CHB), a faculty member of the CHB Clinical Research Program, a member of the NIH-supported Harvard Digestive Diseases Research Center, and Associate Professor of Pediatrics at Harvard Medical School and of Nutrition at the Harvard School of Public Health. Trainees who are supported by two T32 training programs are available as mentees. The proposed research in this K24 award extends Dr. Duggan's ongoing studies, including an NICHD-supported R01 grant that seeks to evaluate the efficacy of micronutrient supplementation in Tanzanian children at risk of diarrhea. He and colleagues will conduct a randomized clinical trial: 1. To determine whether zinc or micronutrient supplementation has an enteropathogen species-specific effect in preventing gastrointestinal infections in Tanzanian children; and 2. To determine whether routine zinc supplementation reduces measures of iron status in Tanzanian children, compared to micronutrient supplements without zinc. This application offers a combination of a highly successful researcher in a supportive and intellectually rich environment. This mid-career investigator award is needed to protect Dr. Duggan's time to mentor beginning investigators in patient-oriented nutrition research and to expand his research in diarrheal diseases.) PUBLIC HEALTH RELEVANCE: Diarrheal diseases are an important world-wide cause of childhood mortality and morbidity. This application for a K24 career development award will evaluate whether zinc supplementation has a species-specific effect in reducing the incidence of diarrhea in Tanzanian children, and will support the mentoring capacity of the applicant to foster the career of young investigators in the areas of nutrition, diarrhea, and global health.