Patient-oriented Research in Pediatric Diarrheal Diseases

以患者为中心的小儿腹泻病研究

• 批准号: 8680269
• 负责人: CHRISTOPHER P DUGGAN
• 金额: $ 19.11万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-19 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8680269
• 关键词: AIDS/HIV problem; Age; Area; Award; Boston; Cause of Death; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Communicable Diseases; Developed Countries; Developing Countries; Diarrhea; Digestive System Disorders; Disease; Enteral Nutrition; Environment; Faculty; Fostering; Funding; Gastroenterology; Gastrointestinal tract structure; Goals; Grant; Growth; Health; Incidence; International; Iron; K-Series Research Career Programs; Malnutrition; Measures; Mentors; Mentorship; Micronutrients; Mid-Career Clinical Scientist Award (K24); Morbidity - disease rate; Multivitamin; National Institute of Child Health and Human Development; Nutritional Study; ORALIT; Oral; Outcome; Parenteral Nutrition; Pediatric Hospitals; Pediatrics; Perinatal; Physicians; Principal Investigator; Productivity; Public Health; Public Health Schools; Randomized Clinical Trials; Rehydration Solutions; Request for Applications; Research; Research Personnel; Respiratory Tract Infections; Risk; Scientist; Short Bowel Syndrome; Supplementation; Time; Training; Training Programs; United States National Institutes of Health; Woman; Work; Zinc; career; gastrointestinal infection; global health; improved; medical schools; member; mortality; nutrition; patient oriented; patient oriented research; prevent; professor; programs; randomized trial; sound

DESCRIPTION (provided by applicant): Diseases of the gastrointestinal tract cause significant morbidity and mortality among children. In developing countries, episodes of infectious diarrhea, including those associated with HIV/AIDS, are major causes of death. In industrialized countries, children with short bowel syndrome suffer from chronic diarrhea requiring treatment with parenteral and enteral nutrition. This revised application requests a mid-career investigator award in patient-oriented research (K24) for Christopher Duggan, MD, MPH. Dr. Duggan's overall research goal is to improve clinical outcomes in diarrheal diseases. He has a record of high productivity in funded research in the fields of nutrition, gastroenterology, and international health. Dr. Duggan has a sound track record of mentoring and excellent opportunities to work with junior investigators. He is Director of Clinical Research in the Division of Gastroenterology and Nutrition at Children's Hospital, Boston (CHB), a faculty member of the CHB Clinical Research Program, a member of the NIH-supported Harvard Digestive Diseases Research Center, and Associate Professor of Pediatrics at Harvard Medical School and of Nutrition at the Harvard School of Public Health. Trainees who are supported by two T32 training programs are available as mentees. The proposed research in this K24 award extends Dr. Duggan's ongoing studies, including an NICHD-supported R01 grant that seeks to evaluate the efficacy of micronutrient supplementation in Tanzanian children at risk of diarrhea. He and colleagues will conduct a randomized clinical trial: 1. To determine whether zinc or micronutrient supplementation has an enteropathogen species-specific effect in preventing gastrointestinal infections in Tanzanian children; and 2. To determine whether routine zinc supplementation reduces measures of iron status in Tanzanian children, compared to micronutrient supplements without zinc. This application offers a combination of a highly successful researcher in a supportive and intellectually rich environment. This mid-career investigator award is needed to protect Dr. Duggan's time to mentor beginning investigators in patient-oriented nutrition research and to expand his research in diarrheal diseases.)

描述（由申请人提供）：胃肠道疾病引起儿童的显着发病率和死亡率。在发展中国家，传染性腹泻的发作（包括与艾滋病毒/艾滋病相关的腹泻）是死亡的主要原因。在工业化国家中，肠综合症短的儿童患有慢性腹泻，需要用肠胃外和肠内营养治疗。该修订后的申请要求为医学博士Christopher Duggan，MPH，授予以患者为导向的研究（K24）的中期研究者奖。 Duggan博士的总体研究目标是改善腹泻疾病的临床结果。他在营养，胃肠病学和国际健康方面的资助研究中拥有高生产力的记录。 Duggan博士拥有指导和与初级调查员合作的绝佳机会的合理记录。他是波士顿儿童医院（CHB）的胃肠病学和营养部临床研究主任，他是CHB临床研究计划的教职员工，NIH支持的哈佛大学消化疾病研究中心的成员，哈佛医学院的儿童副教授，以及哈佛医学院的副教育教授，以及哈佛大学公立医学院的营养。受到两个T32培训计划的支持的学员可以作为受训者提供。该K24奖的拟议研究扩展了Duggan博士正在进行的研究，其中包括一项由NICHD支持的R01赠款，该赠款旨在评估坦桑尼亚儿童补充微量营养素的功效，面临腹泻风险。他及其同事将进行一项随机临床试验：1。确定补充锌或微量营养素是否具有肠病基因特异性作用，可预防坦桑尼亚儿童的胃肠道感染； 2。与没有锌的微量营养素补充剂相比，与无锌补充剂相比，坦桑尼亚儿童的铁状态度量是否会降低锌的量度。该应用程序在支持性和智力丰富的环境中提供了非常成功的研究人员的结合。需要这项中期研究者奖，以保护杜根博士的时间指导研究人员开始研究以患者为导向的营养研究，并扩大其在腹泻疾病方面的研究。）

项目成果

A.S.P.E.N. clinical guidelines: nutrition support of children with human immunodeficiency virus infection.

阿斯彭

• DOI: 10.1177/0148607109346276
• 发表时间: 2009
• 期刊: JPEN. Journal of parenteral and enteral nutrition
• 作者: Sabery,Nasim;Duggan,Christopher;AmericanSocietyforParenteralandEnteralNutritionBoardofDirectors
• 通讯作者: AmericanSocietyforParenteralandEnteralNutritionBoardofDirectors

Innovations in nutrition education and global health: the Bangalore Boston nutrition collaborative.

• DOI: 10.1186/1472-6920-14-5
• 发表时间: 2014-01-08
• 期刊: BMC medical education
• 影响因子: 3.6
• 作者: Kuriyan R;Griffiths JK;Finkelstein JL;Thomas T;Raj T;Bosch RJ;Kurpad AV;Duggan C
• 通讯作者: Duggan C

Nutritional practices and their relationship to clinical outcomes in critically ill children--an international multicenter cohort study*.

• DOI: 10.1097/ccm.0b013e31824e18a8
• 发表时间: 2012-07
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Mehta NM;Bechard LJ;Cahill N;Wang M;Day A;Duggan CP;Heyland DK
• 通讯作者: Heyland DK

Implications of acquired environmental enteric dysfunction for growth and stunting in infants and children living in low- and middle-income countries.

• DOI: 10.1177/156482651303400308
• 发表时间: 2013-09
• 期刊: Food and nutrition bulletin
• 影响因子: 1.9
• 作者: Keusch GT;Rosenberg IH;Denno DM;Duggan C;Guerrant RL;Lavery JV;Tarr PI;Ward HD;Black RE;Nataro JP;Ryan ET;Bhutta ZA;Coovadia H;Lima A;Ramakrishna B;Zaidi AK;Burgess DC;Brewer T
• 通讯作者: Brewer T

Central line-associated bloodstream infections in neonates with gastrointestinal conditions: developing a candidate definition for mucosal barrier injury bloodstream infections.

患有胃肠道疾病的新生儿的中心导管相关血流感染：制定粘膜屏障损伤血流感染的候选定义。

• DOI: 10.1086/678410
• 发表时间: 2014
• 期刊: Infection control and hospital epidemiology
• 影响因子: 4.5
• 作者: Coffin,SusanE;Klieger,SarahB;Duggan,Christopher;Huskins,WCharles;Milstone,AaronM;Potter-Bynoe,Gail;Raphael,Bram;Sandora,ThomasJ;Song,Xiaoyan;Zerr,DanielleM;Lee,GraceM;PediatricPreventionEpiCenterConsortium
• 通讯作者: PediatricPreventionEpiCenterConsortium