Patient-oriented Research in Pediatric Diarrheal Diseases

描述（申请人提供）：胃肠道疾病是儿童发病率和死亡率较高的疾病。在发展中国家，传染性腹泻，包括与艾滋病毒/艾滋病有关的腹泻，是导致死亡的主要原因。在工业化国家，患有短肠综合征的儿童患有慢性腹泻，需要肠外和肠内营养治疗。这一修订后的申请要求为Christopher Duggan，医学博士，公共卫生硕士颁发面向患者研究（K24）的职业中期研究者奖。Duggan博士的总体研究目标是改善腹泻疾病的临床结果。他在营养学、胃肠病学和国际健康领域的资助研究方面有着高生产率的记录。达根博士有着良好的指导经验和与初级调查员合作的绝佳机会。他是波士顿儿童医院（CHB）胃肠病学和营养部门的临床研究主任，CHB临床研究项目的教员，美国国立卫生研究院支持的哈佛消化疾病研究中心的成员，哈佛医学院儿科副教授和哈佛公共卫生学院营养学副教授。由两个T32培训计划支持的学员可作为徒弟。K24奖的拟议研究扩展了Duggan博士正在进行的研究，包括nichud支持的R01资助，旨在评估微量营养素补充对有腹泻风险的坦桑尼亚儿童的功效。他和同事将进行一项随机临床试验：确定锌或微量营养素补充剂在预防坦桑尼亚儿童胃肠道感染方面是否具有肠道病原体物种特异性作用；和2。确定与不补充锌的微量营养素相比，常规补锌是否会降低坦桑尼亚儿童的铁含量。这个应用程序提供了一个非常成功的研究人员在一个支持和智力丰富的环境的组合。这个职业生涯中期的研究者奖是为了保护达根博士的时间，以指导以患者为导向的营养研究的初级研究者，并扩大他在腹泻疾病方面的研究。)

DESCRIPTION (provided by applicant): Diseases of the gastrointestinal tract cause significant morbidity and mortality among children. In developing countries, episodes of infectious diarrhea, including those associated with HIV/AIDS, are major causes of death. In industrialized countries, children with short bowel syndrome suffer from chronic diarrhea requiring treatment with parenteral and enteral nutrition. This revised application requests a mid-career investigator award in patient-oriented research (K24) for Christopher Duggan, MD, MPH. Dr. Duggan's overall research goal is to improve clinical outcomes in diarrheal diseases. He has a record of high productivity in funded research in the fields of nutrition, gastroenterology, and international health. Dr. Duggan has a sound track record of mentoring and excellent opportunities to work with junior investigators. He is Director of Clinical Research in the Division of Gastroenterology and Nutrition at Children's Hospital, Boston (CHB), a faculty member of the CHB Clinical Research Program, a member of the NIH-supported Harvard Digestive Diseases Research Center, and Associate Professor of Pediatrics at Harvard Medical School and of Nutrition at the Harvard School of Public Health. Trainees who are supported by two T32 training programs are available as mentees. The proposed research in this K24 award extends Dr. Duggan's ongoing studies, including an NICHD-supported R01 grant that seeks to evaluate the efficacy of micronutrient supplementation in Tanzanian children at risk of diarrhea. He and colleagues will conduct a randomized clinical trial: 1. To determine whether zinc or micronutrient supplementation has an enteropathogen species-specific effect in preventing gastrointestinal infections in Tanzanian children; and 2. To determine whether routine zinc supplementation reduces measures of iron status in Tanzanian children, compared to micronutrient supplements without zinc. This application offers a combination of a highly successful researcher in a supportive and intellectually rich environment. This mid-career investigator award is needed to protect Dr. Duggan's time to mentor beginning investigators in patient-oriented nutrition research and to expand his research in diarrheal diseases.) PUBLIC HEALTH RELEVANCE: Diarrheal diseases are an important world-wide cause of childhood mortality and morbidity. This application for a K24 career development award will evaluate whether zinc supplementation has a species-specific effect in reducing the incidence of diarrhea in Tanzanian children, and will support the mentoring capacity of the applicant to foster the career of young investigators in the areas of nutrition, diarrhea, and global health.