Patient-oriented Research in Pediatric Diarrheal Diseases

描述（由申请人提供）：胃肠道疾病仍然是全球范围内的重大公共卫生问题。急性和持续性腹泻疾病每年夺走近100万5岁以下儿童的生命。此外，腹泻反复发作会导致营养不良、发育迟缓、神经发育评分降低，并可能增加患某些慢性疾病的风险。虽然口服体液补充液成分的改进减轻了腹泻的负担，但每年仍有数百万儿童死于腹泻病和相关并发症。在工业化国家，患有肠衰竭（短肠综合征和其他疾病）的儿童患有慢性腹泻和营养不良，需要专门的肠外和肠内营养治疗。随着这一职业中期研究者奖的更新，医学博士克里斯托弗·达根（Christopher Duggan）寻求继续扩大他对年轻研究者的指导，并扩大他在改善儿童腹泻疾病临床结果方面的研究。Duggan博士将扩大他在肠道衰竭和消化道疾病领域的研究，与粘膜免疫和健康与疾病的发育起源方面的专家合作。在最初的赠款期间，他在疟疾治疗和预防领域进行了一些重要的研究，并指导了许多年轻的同事。他领导了重要的研究工作，以获得和验证参与他的R01资助的微量营养素临床试验的坦桑尼亚儿童的胃肠道功能的新生物标志物，现在提议在美国肠衰竭儿童中评估这些生物标志物。他是几个完善的T32培训赠款的教员，这将使他能够指导在儿科胃肠病学，营养学，胃肠道手术，全球健康和成果研究领域有杰出前途的医生科学家和研究生。他将继续培养技能和临床研究基础设施，使年轻的研究人员能够沿着富有成效的职业轨迹发展。

DESCRIPTION (provided by applicant): Gastrointestinal diseases continue to be significant public health problems on a worldwide scale. Acute and persistent diarrheal diseases claim nearly one million lives of children under age 5 each year. In addition, repeated episodes of diarrhea lead to malnutrition, stunting, lower neurodevelopment scores, and may increase the risk of some chronic diseases. Although improvements in the composition of oral rehydration solutions have reduced the burden of diarrhea, millions of children die of diarrheal diseases and associated complications each year. In industrialized countries, children with intestinal failure (short bowel syndrome and other disorders) suffer from chronic diarrhea and malnutrition requiring treatment with specialized parenteral and enteral nutrition. With the renewal of this mid-career investigator award, Christopher Duggan, MD, MPH seeks to continue to expand his mentorship of young investigators and extend his research in improving clinical outcomes for children with diarrheal diseases. Dr. Duggan will expand his research in the areas of intestinal failure and diarrheal diseases, collaborating with experts in mucosal immunity and developmental origins of health and disease. During the initial grant period, he performed a number of important studies in the fields of diarrheal disease treatment and prevention, and has mentored numerous young colleagues. He leads important research efforts to derive and validate new biomarkers of gastrointestinal function in Tanzanian children who participated in his R01- funded micronutrient clinical trial, and now proposes to evaluate these biomarkers in US children with intestinal failure. He is a faculty member of several well-established T32 training grants that will allow him to mentor physician scientists and graduate students of outstanding promise in the fields of pediatric gastroenterology, nutrition, GI surgery, global health and outcomes research. He will continue to foster the skills and clinical research infrastructure to enable younger investigators to develop along productive career trajectories.