Patient-oriented Research in Pediatric Diarrheal Diseases

描述(申请人提供)：胃肠道疾病仍然是全球范围内的重大公共卫生问题。每年，急性和持续性腹泻疾病夺走了近100万5岁以下儿童的生命。此外，反复腹泻会导致营养不良、发育迟缓、神经发育评分降低，并可能增加一些慢性病的风险。尽管口服补液液成分的改进减轻了腹泻的负担，但每年仍有数百万儿童死于腹泻疾病和相关并发症。在工业化国家，患有肠衰竭(短肠综合征和其他疾病)的儿童患有慢性腹泻和营养不良，需要专门的肠外和肠内营养治疗。随着这一职业生涯中期研究人员奖的续期，医学博士Christopher Duggan寻求继续扩大他对年轻研究人员的指导，并扩大他在改善腹泻疾病儿童临床结果方面的研究。达根博士将扩大他在肠衰竭和腹泻疾病领域的研究，与粘膜免疫以及健康和疾病的发育起源方面的专家合作。在最初的资助期间，他在腹泻病治疗和预防领域进行了许多重要研究，并指导了许多年轻同事。他领导了重要的研究工作，以获得和验证参与他的R01资助的微量营养素临床试验的坦桑尼亚儿童胃肠功能的新生物标记物，现在他提议在美国肠衰竭儿童中评估这些生物标记物。他是几个久负盛名的T32培训助学金的教员，这些助学金将使他能够指导内科科学家和在儿科胃肠病学、营养学、胃肠外科、全球健康和结果研究领域有杰出前途的研究生。他将继续培养技能和临床研究基础设施，使年轻的研究人员能够沿着富有成效的职业轨迹发展。

DESCRIPTION (provided by applicant): Gastrointestinal diseases continue to be significant public health problems on a worldwide scale. Acute and persistent diarrheal diseases claim nearly one million lives of children under age 5 each year. In addition, repeated episodes of diarrhea lead to malnutrition, stunting, lower neurodevelopment scores, and may increase the risk of some chronic diseases. Although improvements in the composition of oral rehydration solutions have reduced the burden of diarrhea, millions of children die of diarrheal diseases and associated complications each year. In industrialized countries, children with intestinal failure (short bowel syndrome and other disorders) suffer from chronic diarrhea and malnutrition requiring treatment with specialized parenteral and enteral nutrition. With the renewal of this mid-career investigator award, Christopher Duggan, MD, MPH seeks to continue to expand his mentorship of young investigators and extend his research in improving clinical outcomes for children with diarrheal diseases. Dr. Duggan will expand his research in the areas of intestinal failure and diarrheal diseases, collaborating with experts in mucosal immunity and developmental origins of health and disease. During the initial grant period, he performed a number of important studies in the fields of diarrheal disease treatment and prevention, and has mentored numerous young colleagues. He leads important research efforts to derive and validate new biomarkers of gastrointestinal function in Tanzanian children who participated in his R01- funded micronutrient clinical trial, and now proposes to evaluate these biomarkers in US children with intestinal failure. He is a faculty member of several well-established T32 training grants that will allow him to mentor physician scientists and graduate students of outstanding promise in the fields of pediatric gastroenterology, nutrition, GI surgery, global health and outcomes research. He will continue to foster the skills and clinical research infrastructure to enable younger investigators to develop along productive career trajectories.