Assessing the relationship between environmental enteric dysfunction and poor growth via a newly developed 11-plex assay
通过新开发的 11 重检测评估环境肠道功能障碍与生长不良之间的关系
基本信息
- 批准号:10021657
- 负责人:
- 金额:$ 18.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-21 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:5 year oldAdultAffectAgeAge-MonthsAssessment toolBiological AssayBiological MarkersBiological SciencesBirthBirth WeightBirth lengthBloodC-reactive proteinCD14 geneCaregiversChildChild MortalityChildhoodCholecalciferolChronicClinic VisitsCognitiveDataDevelopmentEconomicsEnrollmentEnteralEnvironmentEnvironmental EpidemiologyExposure toFailureFerritinFlagellinFunctional disorderGrowthGrowth and Development functionHIVHealthHeightHistologicHuman DevelopmentHygieneHypertensionImmunoglobulinsIndividualInfantInflammationInsulin-Like Growth Factor IIntestinal permeabilityIntestinesKnowledgeLanguageLengthLifeLinkLipopolysaccharidesLongitudinal cohort studyMalnutritionMeasuresMethodsMicronutrientsMorbidity - disease rateMothersMotorMucositisOrosomucoidOutcomePermeabilityPersonal SatisfactionPlasmodium falciparumPopulationPostpartum PeriodPregnancyPregnant WomenProductivityRBP4 geneRandomizedReportingResearchRiskRoleSamplingSerumSeveritiesSmall IntestinesSomatotropinStandardizationSupplementationSurrogate MothersTFRC geneTanzaniaThyroglobulinTimeVillousVitaminsabsorptionadverse birth outcomesbaseburden of illnesscholecalciferol supplementationcognitive developmentdouble-blind placebo controlled trialenteric pathogenfibroblast growth factor 21gastrointestinalhormone resistanceimprovedin uteroindexinginfancyinflammatory disease of the intestineinnovationintestinal fatty acid binding proteinlow and middle-income countriesmicrobialmortalityneurodevelopmentnutritionscreeningwork-study
项目摘要
Project Summary:
Undernutrition remains one of the greatest human development challenges of our time. In 2017, an
estimated 151 million children < 5 years of age (i.e., 22.2% of the global population) were stunted, increasing
their risk for morbidity and mortality in childhood, suboptimal cognitive development, poorer educational
outcomes, and lower economic productivity and earnings in adulthood. It has been increasingly appreciated
that growth failure can begin in utero and worsen during early infancy; recently, environmental enteric
dysfunction (EED) has been hypothesized as an important causal factor. EED is an acquired, subclinical
condition of the small intestine associated with chronic exposure to an unhygienic environment where enteric
pathogens persist. Histologic features include mucosal inflammation, villous blunting, altered barrier integrity,
and reduced intestinal absorptive capacity. Despite EED’s purported link to poor health and nutrition outcomes
in young children in low- and middle- income countries (LMICs), our knowledge of EED is relatively limited.
Research gaps include the role of infant EED on subsequent poor growth and development and the possible
role of maternal EED on adverse birth outcomes.
The Trial of Vitamins-5 (ToV5) is an individually randomized, double-blind, placebo-controlled trial (R01
HD83113; ClinicalTrials.gov: NCT02305927) of maternal vitamin D3 (cholecalciferol) supplementation
conducted among 2,300 HIV-infected pregnant women in Dar es Salaam, Tanzania. Following enrollment into
the trial, mothers were followed-up at monthly clinic visits during pregnancy, at delivery, and then with their
child at monthly postpartum clinic visits. Using data and serum samples collected in the ToV5 study, the main
objectives of the current proposal are to assess 1) the relationship between infant EED and linear growth, i.e.,
length-for-age Z-score (LAZ) at 12 months of age; 2) the relationship between infant EED and development,
measured by the Caregiver-Reported Early Development Index (CREDI) at 12 months of age; and 3) the
relationship between maternal EED during pregnancy and birth outcomes, primarily infant birth weight and
duration of gestation. We also aim to 4) examine relationships between the EED, systemic inflammation, and
micronutrient biomarkers from a newly developed 11-plex multi-micronutrient and EED assessment tool
(MEEDAT); consisting of intestinal fatty acid–binding protein (I-FABP), soluble CD14 (sCD14), insulin-like
growth factor 1 (IGF-1), fibroblast growth factor 21 (FGF21), alpha-1-acid glycoprotein (AGP), C-reactive
protein (CRP), ferritin, soluble transferrin receptor (sTfR), retinol binding protein 4 (RBP4), thyroglobulin (Tg),
and Plasmodium falciparum exposure (HRP2); and anti-flagellin/anti-LPS Igs. Overall, this proposed research
will contribute to our understanding of the consequences of EED in LMICs, specifically related to poor growth
and adverse birth outcomes, using two innovative methods for assessing EED, namely anti-flagellin/anti-LPS
Igs and MEEDAT.
项目概要:
营养不良仍然是当今时代人类发展面临的最大挑战之一。 2017 年,
据估计,有 1.51 亿 5 岁以下儿童(即全球人口的 22.2%)发育迟缓,
儿童时期发病和死亡的风险、认知发展欠佳、教育水平较差
的结果,以及成年期经济生产力和收入的降低。已经越来越受到人们的重视
生长障碍可能在子宫内开始,并在婴儿早期恶化;最近,环保肠
功能障碍(EED)被认为是一个重要的致病因素。 EED 是一种获得性、亚临床的
与长期暴露于不卫生的环境有关的小肠状况
病原体持续存在。组织学特征包括粘膜炎症、绒毛变钝、屏障完整性改变、
以及肠道吸收能力下降。尽管 EED 据称与不良健康和营养结果有关
对于低收入和中等收入国家 (LMIC) 的幼儿,我们对 EED 的了解相对有限。
研究差距包括婴儿 EED 对随后生长发育不良的作用以及可能的影响
母亲 EED 对不良分娩结果的作用。
Vitamins-5 试验 (ToV5) 是一项单独随机、双盲、安慰剂对照试验 (R01
HD83113; ClinicalTrials.gov:NCT02305927) 孕妇维生素 D3(胆钙化醇)补充剂
在坦桑尼亚达累斯萨拉姆对 2,300 名感染艾滋病毒的孕妇进行了研究。入学后
在该试验中,母亲们在怀孕期间、分娩时以及她们的情况下每月进行一次门诊随访。
孩子每月进行产后门诊就诊。使用 ToV5 研究中收集的数据和血清样本,主要
当前提案的目标是评估 1) 婴儿 EED 和线性生长之间的关系,即
12 个月大时的年龄别身长 Z 得分 (LAZ); 2)婴儿EED与发育之间的关系,
根据 12 个月大时看护者报告的早期发育指数 (CREDI) 进行测量; 3)
母亲怀孕期间 EED 与出生结果(主要是婴儿出生体重)之间的关系
妊娠持续时间。我们还旨在 4) 检查 EED、全身炎症和
来自新开发的 11 重多种微量营养素和 EED 评估工具的微量营养素生物标志物
(MEEDAT);由肠脂肪酸结合蛋白 (I-FABP)、可溶性 CD14 (sCD14)、胰岛素样物质组成
生长因子 1 (IGF-1)、成纤维细胞生长因子 21 (FGF21)、α-1-酸性糖蛋白 (AGP)、C 反应性
蛋白 (CRP)、铁蛋白、可溶性转铁蛋白受体 (sTfR)、视黄醇结合蛋白 4 (RBP4)、甲状腺球蛋白 (Tg)、
恶性疟原虫暴露(HRP2);和抗鞭毛蛋白/抗 LPS Igs。总体而言,本提议的研究
将有助于我们了解 EED 对中低收入国家的影响,特别是与经济增长不良相关的影响
和不良出生结局,使用两种创新方法评估 EED,即抗鞭毛蛋白/抗 LPS
Igs 和 MEEDAT。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHRISTOPHER P DUGGAN其他文献
CHRISTOPHER P DUGGAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHRISTOPHER P DUGGAN', 18)}}的其他基金
Trial of Zinc Supplements for Young Infants with Clinical Severe Infection in Tanzania
在坦桑尼亚对患有临床严重感染的小婴儿进行锌补充剂试验
- 批准号:
10635077 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Patient-oriented Research in Pediatric Diarrheal Diseases
以患者为中心的小儿腹泻病研究
- 批准号:
8680269 - 财政年份:2010
- 资助金额:
$ 18.52万 - 项目类别:
Patient-oriented Research in Pediatric Diarrheal Diseases
以患者为中心的小儿腹泻病研究
- 批准号:
8471737 - 财政年份:2010
- 资助金额:
$ 18.52万 - 项目类别:
Patient-oriented Research in Pediatric Diarrheal Diseases
以患者为中心的小儿腹泻病研究
- 批准号:
8294784 - 财政年份:2010
- 资助金额:
$ 18.52万 - 项目类别:
Patient-oriented Research in Pediatric Diarrheal Diseases
以患者为中心的小儿腹泻病研究
- 批准号:
8113298 - 财政年份:2010
- 资助金额:
$ 18.52万 - 项目类别:
Patient-oriented Research in Pediatric Diarrheal Diseases
以患者为中心的小儿腹泻病研究
- 批准号:
7892835 - 财政年份:2010
- 资助金额:
$ 18.52万 - 项目类别:
Patient-oriented Research in Pediatric Diarrheal Diseases
以患者为中心的小儿腹泻病研究
- 批准号:
9115582 - 财政年份:2008
- 资助金额:
$ 18.52万 - 项目类别:
Randomized trial of vitamin B12 in pregnant Indian women
印度孕妇维生素 B12 的随机试验
- 批准号:
7231556 - 财政年份:2007
- 资助金额:
$ 18.52万 - 项目类别:
NUTRITION SUPPORT IN PEDIATRIC STEM CELL TRANSPLANTATION - A RCT
儿科干细胞移植中的营养支持 - 随机对照试验
- 批准号:
7607255 - 财政年份:2007
- 资助金额:
$ 18.52万 - 项目类别:
A Trial of Zinc and Micronutrients in Tanzanian Children
坦桑尼亚儿童的锌和微量营养素试验
- 批准号:
7270675 - 财政年份:2006
- 资助金额:
$ 18.52万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 18.52万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 18.52万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 18.52万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 18.52万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 18.52万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 18.52万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Grant-in-Aid for Scientific Research (C)














{{item.name}}会员




