BONE DENSITY IN HIV-INFECTED WOMEN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。确定HAART时代健康HIV感染女性人群中骨质减少和骨质疏松的患病率是否高于预期。确定该人群中骨质减少和骨质疏松症的风险因素，确定蛋白酶抑制剂的使用和身体成分变化（脂肪代谢障碍）是否有助于HIV感染女性的骨密度降低，如先前在HIV阳性男性中所记录的那样，并通过分析炎性细胞因子和骨转换标志物来确定HIV感染女性中骨质减少的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine whether the population of healthy HIV-infected women in the era of HAART exhibits a higher than expected prevalence of osteopenia and osteoporosis. Identify risk factors of osteopenia and osteoporosis in this population, determine whether protease inhibitor use and body composition changes (lipodystrophy) contribute to reduced bone density in HIV-infected women as has previously been documented in HIV-positive men and identify mechanisms of osteopenia in HIV-infected women via analysis of inflammatory cytokines and bone turnover markers.