A PILOT OPEN-LABELED TRIAL OF SAM-E FOR RECURRENT ABDOMINAL PAIN IN CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将在一项开放的标签试点试验中评估SAM-e作为儿童复发性腹痛(RAP)的治疗方法。我们的具体目标是： 1.确定SAM-e是否能降低反复腹痛儿童的疼痛强度、无疼痛症状、疼痛残疾和抑郁症状。 2.确定SAM-e是否能提高反复腹痛儿童的健康相关生活质量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will evaluate SAM-e as a treatment for recurrent abdominal pain (RAP) in children in an open labeled pilot trial. Our specific aims will be: 1. To determine whether SAM-e reduces pain intensity, non-pain symptoms, pain disability, and depressive symptoms in children with recurrent abdominal pain. 2. To determine whether SAM-e increases the health-related quality of life in children with recurrent abdominal pain.