PACE-CALL: A TAILORED WEIGHT MANAGEMENT PROGRAM FOR CHILDHOOD ALL SURVIVORS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的： 开发和定制专门针对儿童ALL青少年幸存者（PACE-CALL）的减肥行为干预，并确定PACE-CALL干预6个月时对BMI-z评分的影响，并与增强标准干预（ESI）的影响进行比较。 假设：研究期间，与ESI对照组相比，PACE-CALL受试者的BMI-z评分降低幅度更大。 次要目标： 1.确定PACE-CALL与ESI对饮食和体力活动自我报告行为测量的影响。 2.确定PACE-CALL与ESI对身体活动（加速度计）的客观指标以及选定的代谢和生理指标（包括血清类胡萝卜素、空腹血清胰岛素、空腹血 血糖和血脂水平。 3.确定PACE-CALL与ESI对改变的影响，包括改变阶段、行为改变策略的使用、改变的益处和障碍、自我效能和社会支持 4.确定PACE-CALL与ESI对生活质量和抑郁的影响。 5.比较参与者、其家属和参与临床工作人员对PACE-CALL与ESI的可用性和可接受性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Aim: To develop and tailor a weight loss behavioral intervention specifically for adolescent survivors of childhood ALL (PACE-CALL) and to determine the impact at 6 months of the PACE-CALL intervention on BMI-z score as compared to the effect of an Enhanced Standard Intervention (ESI). Hypothesis: PACE-CALL subjects will demonstrate greater reduction in BMI-z score as compared to ESI controls during the study period. Secondary Aims: 1. To determine the impact of PACE-CALL vs. ESI on self-reported behavioral measures of diet and physical activity. 2. To determine the impact of PACE-CALL vs. ESI on objective measures of physical activity (accelerometer), and selected metabolic and physiological measures including serum carotenoids, fasting serum insulin, fasting blood glucose, and blood lipid levels. 3. To determine the impact of PACE-CALL vs. ESI on changes, including stage of change, use of behavior change strategies, benefits and barriers of change, selfefficacy, and social support 4. To determine the impact of PACE-CALL vs. ESI on quality of life and depression. 5. To compare usability and acceptability of PACE-CALL vs. ESI by participants, their families, and participating clinical staff.