PACE-CALL: A TAILORED WEIGHT MANAGEMENT PROGRAM FOR CHILDHOOD ALL SURVIVORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 主要目标： 开发和定制专门针对儿童ALL青春期幸存者的减肥行为干预(PACE-CALL)，并确定PACE-CALL干预6个月时与增强型标准干预(ESI)的效果比较对BMI-Z评分的影响。 假设：在研究期间，与ESI对照组相比，PACE-Call受试者的BMI-z得分将有更大的下降。 次要目标： 1.确定Pace-Call与ESI对自我报告的饮食和体力活动行为指标的影响。 2.确定Pace-Call与ESI对客观体力活动指标(加速计)的影响，以及选定的代谢和生理指标，包括血清类胡萝卜素、空腹血清胰岛素、空腹血液 血糖和血脂水平。 3.确定Pace-Call与ESI对改变的影响，包括改变的阶段、行为改变策略的使用、改变的好处和障碍、自我效能和社会支持 4.确定Pace-Call与ESI对生活质量和抑郁的影响。 5.比较参与者、他们的家人和参与研究的临床工作人员对PACE-Call和ESI的可用性和可接受性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Aim: To develop and tailor a weight loss behavioral intervention specifically for adolescent survivors of childhood ALL (PACE-CALL) and to determine the impact at 6 months of the PACE-CALL intervention on BMI-z score as compared to the effect of an Enhanced Standard Intervention (ESI). Hypothesis: PACE-CALL subjects will demonstrate greater reduction in BMI-z score as compared to ESI controls during the study period. Secondary Aims: 1. To determine the impact of PACE-CALL vs. ESI on self-reported behavioral measures of diet and physical activity. 2. To determine the impact of PACE-CALL vs. ESI on objective measures of physical activity (accelerometer), and selected metabolic and physiological measures including serum carotenoids, fasting serum insulin, fasting blood glucose, and blood lipid levels. 3. To determine the impact of PACE-CALL vs. ESI on changes, including stage of change, use of behavior change strategies, benefits and barriers of change, selfefficacy, and social support 4. To determine the impact of PACE-CALL vs. ESI on quality of life and depression. 5. To compare usability and acceptability of PACE-CALL vs. ESI by participants, their families, and participating clinical staff.