PREVALENCE OF VITAMIN D DEFICIENCY IN PATIENTS ADMITTED TO REHABILITATION UNIT

入住康复科的患者维生素 D 缺乏症的患病率

• 批准号: 7379503
• 负责人: MICHAEL F. HOLICK
• 金额: $ 1.27万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379503
• 关键词: PREVALENCE; VITAMIN; DEFICIENCY; PATIENTS; ADMITTED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vitamin D deficiency is assumed to be a problem of the past and therefore not in the forefront of treatment by the medical community. The truth is vitamin D deficiency is a chronic problem seen in all age groups and a variety of ethnic groups. Recently, it is recognized that vitamin D deficiency is an especially common problem in hospitalized and nursing home patients. Advanced age, inadequate vitamin D intake, and housebound living put patients at increased risk for Vitamin D deficiency, but on its own are insufficient to predict hypovitaminosis. The vitamin D status is important for the health and well being of patients after recent hospitalization after an acute illness or surgery. Given the nature of patient population admitted for rehabilitation at the Transitional Care Unit, we believe that it is important to characterize the prevalence of vitamin D deficiency in this subgroup. Thus, we are interested in measuring 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium, albumin and alkaline phosphatase. We will characterize the extent of osteoporosis by measuring bone density and serum CTX - the assay for measurement of bone resorption activity. All participants will fill out a questionnaire with demographic information, history of sun exposure, pertinent medical and medication history. We plan on measuring 25(OH)D, parathyroid hormone, calcium, albumin, alkaline phosphatase, and serum CTX. 20 mL of blood will be collected from the patients during routine blood draw at the time of admission. Patients will also undergo bone densitometry. There are no other study procedures required and there are no other study visits required. Patients will not be compensated for participation. This is an observational study to determine deficiency of vitamin D in patients admitted to the rehabilitation facility as well as to characterize extent of osteoporosis in this population. The outcomes of interest are the levels of the 25 (OH)D, calcium, alkaline phosphatase, albumin, parathyroid hormone, serum CTX and bone density.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。维生素D缺乏症被认为是过去的问题，因此不在医学界治疗的最前沿。事实上，维生素D缺乏是一个慢性问题，在所有年龄组和各种种族中都可以看到。最近，人们认识到维生素D缺乏症是住院和疗养院患者中特别常见的问题。高龄、维生素D摄入不足和居家生活使患者维生素D缺乏的风险增加，但其本身不足以预测维生素缺乏症。 维生素D状态对急性疾病或手术后最近住院的患者的健康和福祉很重要。考虑到在过渡性监护室接受康复治疗的患者人群的性质，我们认为，重要的是要描述该亚组中维生素D缺乏症的患病率。因此，我们有兴趣测量25-羟基维生素D [25（OH）D]，甲状旁腺激素，钙，白蛋白和碱性磷酸酶。我们将通过测量骨密度和血清CTX（用于测量骨吸收活性的测定）来表征骨质疏松的程度。所有参与者将填写一份问卷，其中包括人口统计信息、阳光照射史、相关医疗和药物史。 我们计划测量25（OH）D、甲状旁腺激素、钙、白蛋白、碱性磷酸酶和血清CTX。在入院时的常规抽血期间，将从患者中采集20 mL血液。患者还将接受骨密度测定。无需其他研究程序，也无需其他研究访视。患者不会因参与研究而获得补偿。 这是一项观察性研究，旨在确定入住康复机构的患者的维生素D缺乏情况，并描述该人群骨质疏松症的程度。关注的结果是25（OH）D、钙、碱性磷酸酶、白蛋白、甲状旁腺激素、血清CTX和骨密度的水平。