FLOOD LAMP ULTRAVIOLET RAYS AND VITAMIN D

泛光灯紫外线和维生素 D

• 批准号: 7379518
• 负责人: MICHAEL F. HOLICK
• 金额: $ 8.8万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379518
• 关键词: FLOOD; LAMP; ULTRAVIOLET; RAYS; VITAMIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this clinical research protocol is to determine the quantitative changes in circulating concentrations of vitamin D and its metabolites and other parameters of calcium and bone metabolism in response to multiple suberythemal exposures (of the abdomen, arms, back or legs) to simulated sunlight from a marketed flood lamp that emits ultraviolet light. Blood samples for determining vitamin D, 25-hydroxyvitamin D, parathyroid hormone, C-telopeptide (CTX), calcium, and albumin will be obtained before initiation of the protocol and at weekly intervals throughout the 1 month study. Subjects will go to the GCRC 3 times a week for 4 weeks, be in front of a flood lamp for 1 to 2 minutes (depending on skin type), and have blood drawn at baseline, beginning of week 2, week 3, week 4 and at final visit.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该临床研究方案的主要目的是确定维生素D及其代谢产物的循环浓度的定量变化以及钙和骨代谢的其他参数，以响应多种suberythemal暴露（腹部，手臂或腿部）的多个suberythemal暴露，以从燃料的洪水灯中模拟的太阳光，该洪水是Ultoraviolet Light的销售洪水灯。用于确定维生素D，25-羟基维生素D，甲状旁腺激素，C-甲基肽（CTX），钙和白蛋白的血液样本将在整个1个月的研究中以每周的时间间隔启动之前获得。受试者每周将3次进入GCRC，持续4周，在洪水灯前持续1至2分钟（取决于皮肤类型），并在基线上抽血，第2周开始，第3周，第4周，第4周和最终访问。