FLOOD LAMP ULTRAVIOLET RAYS AND VITAMIN D

泛光灯紫外线和维生素 D

• 批准号: 7379518
• 负责人: MICHAEL F. HOLICK
• 金额: $ 8.8万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379518
• 关键词: FLOOD; LAMP; ULTRAVIOLET; RAYS; VITAMIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this clinical research protocol is to determine the quantitative changes in circulating concentrations of vitamin D and its metabolites and other parameters of calcium and bone metabolism in response to multiple suberythemal exposures (of the abdomen, arms, back or legs) to simulated sunlight from a marketed flood lamp that emits ultraviolet light. Blood samples for determining vitamin D, 25-hydroxyvitamin D, parathyroid hormone, C-telopeptide (CTX), calcium, and albumin will be obtained before initiation of the protocol and at weekly intervals throughout the 1 month study. Subjects will go to the GCRC 3 times a week for 4 weeks, be in front of a flood lamp for 1 to 2 minutes (depending on skin type), and have blood drawn at baseline, beginning of week 2, week 3, week 4 and at final visit.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本临床研究方案的主要目标是确定维生素D及其代谢物的循环浓度的定量变化，以及钙和骨代谢的其他参数，以应对多次红肿下暴露（腹部、手臂、背部或腿部）的模拟阳光，从市场上销售的发射紫外线的泛光灯。血液样本用于测定维生素D， 25-羟基维生素D，甲状旁腺激素，c -末端肽（CTX），钙和白蛋白将在方案开始前和在整个1个月的研究中每周间隔一次。受试者将每周去GCRC 3次，持续4周，在泛光灯前1至2分钟（取决于皮肤类型），并在基线、第2周开始、第3周、第4周和最后一次就诊时抽血。