EFFECTS OF ULTRAVIOLET IRRADIATION ON VITAMIN D AND CALCIUM

紫外线照射对维生素 D 和钙的影响

• 批准号: 7379460
• 负责人: MICHAEL F. HOLICK
• 金额: $ 2.16万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379460
• 关键词: EFFECTS; ULTRAVIOLET; IRRADIATION; VITAMIN; CALCIUM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this clinical research protocol is to determine, in adults with varying skin types, the quantitative changes in circulating concentrations of vitamin D and its metabolites in response to multiple suberythemal exposures to simulated sunlight. Patients will be exposed to a tanning bed for three months during late fall and winter. It is hypothesized that exposure to tanning bed radiation will increase serum vitamin D and 25(OH)D levels, and reduce serum PTH and urine NTX in subjects who are vitamin D insufficient. The secondary goal of this clinical research protocol is to quantitatively measure from punch biopsies, the expression of genes related to vitamin D metabolism, cell proliferation and differentiation, DNA damage and repair, B-endorphin and circadian rhythm. In addition, we will measure skin pigmentation before and immediately after each irradiation during the study using Datacolor microflash spectrophotometer to quantitate the degree of melanin pigmentation and any erythema that results from exposures to simulated sunlight in a tanning be

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本临床研究方案的主要目标是确定不同皮肤类型的成人中，维生素D及其代谢物循环浓度的定量变化，以响应多次皮下暴露于模拟阳光。在秋末和冬季，患者将暴露在日光浴床下三个月。假设暴露于晒黑床辐射将增加血清维生素D和25（OH）D水平，并降低维生素D不足的受试者的血清PTH和尿NTX。本临床研究方案的第二个目标是从穿刺活检中定量测量与维生素D代谢、细胞增殖和分化、DNA损伤和修复、B-内啡肽和昼夜节律相关的基因表达。此外，我们将在研究期间使用Datacolor微闪分光光度计在每次照射之前和之后立即测量皮肤色素沉着，以定量黑色素沉着的程度和晒黑过程中暴露于模拟阳光导致的任何红斑。