CALCIUM METABOLISM IN ASIAN ADOLESCENTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。先前在青少年白色和黑人女孩和男孩中开展的工作（GCRC方案0451）已经确定了优化这些群体骨骼钙保留的膳食钙摄入量。 该方案涉及在Purdue进行的2周钙平衡，并在平衡的第一天对GCRC进行钙动力学研究。在高钙摄入量和低钙摄入量下，对每名受试者间隔一个月进行两次平衡，钙摄入量范围为600-2300 mg/d。我们现在建议研究这些相同的关系在华裔美国青少年的女孩和男孩。主要目的是建立优化亚洲女孩和男孩骨骼钙保留的钙需求。 第二个目的是将亚洲人的数据与我们已经在美国白人和黑人中收集的数据进行比较。长期目标是在快速生长期间建立最佳钙摄入量，以建立峰值骨量并降低骨质疏松症的终身风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work ( GCRC protocol 0451) in adolescent white and black girls and boys has established the dietary calcium intake that optimizes skeletal calcium retention in these groups. The protocol involves a 2 week calcium balance at Purdue with calcium kinetics performed on the GCRC on day one of the balance. Two balances are performed one month apart on each subject on a high and low calcium intake with the range of calcium intakes lying between 600-2300 mg/d. We now propose to study these same relationships in Chinese American adolescent girls and boys. The primary aim is to establish the calcium requirement that optimizes skeletal calcium retention in Asian girls and boys. A secondary aim is to compare the data in Asians with those we have already collected in American whites and Blacks The long term goal is to establish the optimal calcium intake during periods of rapid growth in order to build peak bone mass and reduce lifelong risk of osteoporosis.