DO DIETARY SUPPLEMENTS OF ZINC REDUCE SERUM CADMIUM LEVELS IN SMOKERS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。镉是一种环境污染物，已知会导致肾脏疾病、骨质疏松症和肺癌。这是因为在人体内，镉与一种对健康至关重要的金属--锌展开竞争。香烟是镉的主要来源，吸烟者体内产生的镉含量是不吸烟者的4-5倍。锌被作为一种降低镉水平的方法推销给吸烟者；然而，锌是否真的能降低吸烟者血液中的镉含量尚不清楚。这项研究的目的是确定吸烟者补充锌是否会降低他们血液中的镉水平。30名吸烟者将被招募，在12周内每天服用80毫克锌的口服补充剂，并大约每两周去GCRC检查一次，以测定血液和尿液中的镉水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cadmium is an environmental pollutant and known cause of kidney disease, osteoporosis and lung cancer. This occurs because in the human body, cadmium competes for a metal essential to health, zinc. Cigarettes, a major source of cadmium, create cadmium levels in smokers 4-5 times higher than in nonsmokers. Zinc is marketed to smokers as a way to reduce cadmium levels; however, whether zinc does reduce cadmium in the blood of smokers is unknown. The objective of this study is to determine if zinc supplementation in smokers will reduce the cadmium levels in their blood. Thirty smokers will be recruited to take daily oral supplements of 80mg zinc for 12 weeks with visits to GCRC approximately every two weeks to determine cadmium levels in blood and urine.