DO DIETARY SUPPLEMENTS OF ZINC REDUCE SERUM CADMIUM LEVELS IN SMOKERS

膳食补充剂锌是否可以降低吸烟者的血清镉水平

• 批准号: 7607680
• 负责人: GARY G SCHWARTZ
• 金额: $ 0.26万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607680
• 关键词: Blood; Cadmium; Cigarette; Computer Retrieval of Information on Scientific Projects Database; Daily; Environmental Pollutants; Funding; Grant; Health; Human body; Institution; Kidney Diseases; Malignant neoplasm of lung; Marketing; Metals; Oral; Osteoporosis; Recruitment Activity; Research; Research Personnel; Resources; Serum; Smoker; Source; Supplementation; Time; United States National Institutes of Health; Urine; Visit; Week; Zinc; dietary supplements; non-smoker

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cadmium is an environmental pollutant and known cause of kidney disease, osteoporosis and lung cancer. This occurs because in the human body, cadmium competes for a metal essential to health, zinc. Cigarettes, a major source of cadmium, create cadmium levels in smokers 4-5 times higher than in nonsmokers. Zinc is marketed to smokers as a way to reduce cadmium levels; however, whether zinc does reduce cadmium in the blood of smokers is unknown. The objective of this study is to determine if zinc supplementation in smokers will reduce the cadmium levels in their blood. Thirty smokers will be recruited to take daily oral supplements of 80mg zinc for 12 weeks with visits to GCRC approximately every two weeks to determine cadmium levels in blood and urine.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 镉是一种环境污染物，已知会导致肾脏疾病、骨质疏松症和肺癌。发生这种情况是因为在人体内，镉会竞争对健康至关重要的金属锌。香烟是镉的主要来源，吸烟者体内的镉含量比不吸烟者高 4-5 倍。锌被作为降低镉含量的一种方法向吸烟者推销；然而，锌是否能减少吸烟者血液中的镉尚不清楚。本研究的目的是确定吸烟者补充锌是否会降低其血液中的镉含量。将招募 30 名吸烟者，每天口服 80 毫克锌补充剂，持续 12 周，并大约每两周拜访 GCRC 一次，以确定血液和尿液中的镉含量。