DO DIETARY SUPPLEMENTS OF ZINC REDUCE SERUM CADMIUM LEVELS IN SMOKERS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 镉是一种环境污染物，已知会导致肾病、骨质疏松症和肺癌。这是因为在人体内，镉会与一种对健康至关重要的金属锌竞争。香烟是镉的主要来源，吸烟者体内的镉含量是不吸烟者的4 - 5倍。锌是作为一种降低镉含量的方法出售给吸烟者的;然而，锌是否能降低吸烟者血液中的镉含量尚不清楚。本研究的目的是确定吸烟者补充锌是否会降低其血液中的镉水平。将招募30名吸烟者，每天口服80 mg锌补充剂，持续12周，大约每两周访问一次GCRC，以确定血液和尿液中的镉水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cadmium is an environmental pollutant and known cause of kidney disease, osteoporosis and lung cancer. This occurs because in the human body, cadmium competes for a metal essential to health, zinc. Cigarettes, a major source of cadmium, create cadmium levels in smokers 4-5 times higher than in nonsmokers. Zinc is marketed to smokers as a way to reduce cadmium levels; however, whether zinc does reduce cadmium in the blood of smokers is unknown. The objective of this study is to determine if zinc supplementation in smokers will reduce the cadmium levels in their blood. Thirty smokers will be recruited to take daily oral supplements of 80mg zinc for 12 weeks with visits to GCRC approximately every two weeks to determine cadmium levels in blood and urine.