PACTG 1025

PACTG 1025

• 批准号: 7377350
• 负责人: Juan C Salazar
• 金额: $ 0.27万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377350
• 关键词: PACTG; 1025

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PACTG P1025 is a prospective cohort study that provides a framework for collection and evlauation of data and collection of repository specimens from HIV-infected pregnant and postpartum women and their infants. The primary objectives of this study are: to assess the effectiveness of interventions (e.g. antiretroviral therapy and mode of delivery) prescribed for prevention of vertical transmission of HIV and/or for women's health; to assess material and infant safety of interventions (e.g. ART and mode of delivery) prescribed for women's health and/or for prevention of vertical transmission of HIV; to provide a framework and specimen repository for intensive substudies (such as PACTG P1026s, pharmacokinetics in pregnancy), New Works Concept Sheets (NWCS) and Data Analysis Concept Sheets (DACS) that aim to further elucidate risk factors for and mechanisms of vertical transmission of HIV, as well as factors that affect maternal and infant outcomes; to assess adherence to ART among HIV-infected pregnant women during pregnancy and postpartum and its impact on women's health and vertical transmission, and to assess adherence to chemoprophylaxsis in infants.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。 PACTG P1025 是一项前瞻性队列研究，为收集和评估感染艾滋病毒的孕妇和产后妇女及其婴儿的数据和储存样本提供了一个框架。本研究的主要目标是： 评估为预防艾滋病毒垂直传播和/或妇女健康而规定的干预措施（例如抗逆转录病毒治疗和分娩方式）的有效性；评估为妇女健康和/或预防艾滋病毒垂直传播而规定的干预措施（例如抗逆转录病毒治疗和分娩方式）的材料和婴儿安全性；为深入的子研究（如PACTG P1026、妊娠期药代动力学）、新工作概念表（NWCS）和数据分析概念表（DACS）提供框架和样本库，旨在进一步阐明艾滋病毒垂直传播的危险因素和机制，以及影响母婴结局的因素；评估感染艾滋病毒的孕妇在怀孕期间和产后对抗逆转录病毒治疗的依从性及其对妇女健康和垂直传播的影响，并评估婴儿对化学预防的依从性。