PACTG 390

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的主要目标是：比较两种NRTI加一种蛋白水解酶抑制剂(PI)和两种NRTI加一种非核苷逆转录酶抑制剂(NNRTI)作为初始治疗的组合，如果失败，随后进行二线治疗，就它们对长期病毒学终点的影响而言，并比较在30天和18岁的HIV抗逆转录病毒幼稚儿童中从一线治疗切换到二线治疗的两种不同的病毒载量标准。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this study are: to compare the combination of 2 NRTIs plus a protease inhibitor (PI) versus 2 NRTIs plus a non-nucleoside reverse transciptase inhibitor (NNRTI) as initial therapy, followed by second-line therapy if failure occurs, in terms of their effects on a long-term virologic endpoint and to compare two different viral load criteria for switching from first-line to second-line therapy in HIV Antiretroviral Naive Children > 30 Days and < 18 years of age.