ANALYSIS OF GENE EXPRESSION IN THE SKIN OF PATIENTS TREATED WITH ISOTRETINON

异维A酮治疗患者皮肤基因表达分析

• 批准号: 7378457
• 负责人: DIANE M. THIBOUTOT
• 金额: $ 0.09万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378457
• 关键词: ANALYSIS; GENE; EXPRESSION; SKIN; PATIENTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of this research is to investigate the mechanisms regulating lipid production in human sebaceous glands. The hypothesis to be tested in this study is that treatment of patients with isotretinoin for acne will cause changes in the expression of genes encoding transcription factors and enzymes involved in lipid metabolism in the skin.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的总体目的是探讨调节人体皮脂腺脂质产生的机制。本研究要验证的假设是，使用异维a酸治疗痤疮患者会导致编码皮肤脂质代谢相关转录因子和酶的基因表达发生变化。