LONG-TERM OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮的长期结果

• 批准号: 7374511
• 负责人: Hermine I Brunner
• 金额: $ 0.53万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374511
• 关键词: LONG; TERM; OUTCOMES; SYSTEMIC; LUPUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Automated Neuropsychological Assessment Metrics (ANAM) is a software program that utilizes measures and specifications developed in various branches of the Armed Forces to create a performance battery sensitive to cognitive change. Several studies have demonstrated the ability of the ANAM to capture subtle cognitive change associated with mild traumatic brain injury (MTBI). Performance decrements on the ANAM were observed even in those individuals with MTBI without decrement on traditional neuropsychological tests. Recent findings demonstrate the ANAM's ability to track deterioration and recovery of cognitive functioning following sports-related concussion injury in young adult males. The ANAM has been used for the assessment of cognitive impairment in adult SLE. The pediatric adaptation of the ANAM has been recently developed and initial validation studies have been performed. Whether this battery is useful for pediatric NPSLE will be studied in this protocol. In this study, patient self reports of neuropsychiatric symptoms will be compared with the results of formal neurocognitive testing. In adults, there is a significant association between higher subjective complaint scores and lower cognitive function as determined by formal neurocognitive testing. Similar studies have not yet been done in childhood onset systemic lupus erythematosus and are a focus of the presented research study. A Self Assessment Neuropsychiatric Questionnaire (NSAQ) similar to the one described in the studies above used in adults, was adapted for children and will be used to determine if self reports of cognition are comparable to the current standard of formal neurocognitive testing.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。自动化神经心理评估指标(ANAM)是一个软件程序，它利用武装部队不同部门开发的措施和规范来创建对认知变化敏感的性能电池。几项研究已经证明，ANAM能够捕捉与轻度创伤性脑损伤(MTBI)相关的细微认知变化。即使在那些在传统神经心理测试中没有下降的MTBI患者中，也观察到ANAM的表现下降。最近的发现表明，ANAM有能力跟踪年轻成年男性运动相关脑震荡损伤后认知功能的恶化和恢复。ANAM已用于评估成人系统性红斑狼疮患者的认知损害。最近开发了ANAM的儿科适应，并进行了初步的验证研究。这种电池是否对儿童NPSLE有用，将在本方案中进行研究。在这项研究中，患者自我报告的神经精神症状将与正式的神经认知测试结果进行比较。在成年人中，由正式的神经认知测试确定的较高的主观抱怨分数和较低的认知功能之间存在显著的关联。类似的研究还没有在儿童起病的系统性红斑狼疮中进行，这是本研究的重点。与上述研究中用于成人的自我评估神经精神病学问卷(NSAQ)类似，该问卷适用于儿童，将用于确定自我认知报告是否可与目前正式神经认知测试的标准相媲美。