CHROMIUM TREATMENT OF HIV-RELATED INSULIN RESISTANCE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究旨在探讨营养补充剂吡啶甲酸铬。大量的人使用保健食品店的吡啶甲酸铬来改善胰岛素激素的功能。我们正在测试这种补充剂的有效性，我们也在监测其安全性。由于艾滋病毒的多种药物治疗会导致对胰岛素不敏感或抵抗，我们正在研究有记录的胰岛素抵抗的艾滋病毒阳性患者。在糖尿病患者中，铬已被证明可以增加对激素胰岛素的敏感性。我们想知道铬在治疗与艾滋病毒相关的耐药性方面是否也有效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is to investigate the nutritional supplement chromium picolinate. A large number of people use chromium picolinate from health food stores to improve function of the hormone insulin. We are testing how effective this supplement is and we are also monitoring its safety. SInce multidrug treatment for HIV can cause insensitivity or resistance to insulin, we are studying HIV positive individuals with documented insulin resistance. In patients with diabetes, chromium has been shown to increase sensitivity to the hormone insulin. We would like to know if chromium is also effective in treating resistance associated with HIV disease.