MECHANISMS OF CHROMIUM'S EFFECT ON INSULIN SENSITIVITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。虽然几种药物在治疗与2型糖尿病相关的胰岛素抵抗方面是有效的，但膳食补充剂吡啶甲酸铬对HIV疾病患者具有特别的优势。这种膳食补充剂已被证明可以改善2型糖尿病患者的胰岛素敏感性。该试验项目将研究1000微克铬作为吡啶甲酸铬对艾滋病毒疾病的胰岛素抵抗的影响。在4个月的治疗过程中，每天给予铬补充剂，并在基线和治疗2个月和4个月后测定胰岛素敏感性。将每2周监测一次可能的毒性。该试验数据将用作铬改善胰岛素敏感性机制的更大研究的初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although several drugs are effective in treating the insulin resistance associated with Type 2 diabetes mellitus, the dietary supplement chromium picolinate has particular advantages for patients with HIV-disease. This dietary supplement has been shown to improve insulin sensitivity in patients with Type 2 diabetes mellitus. This pilot project will investigate the effect of 1000 ug of chromium as chromium picolinate on the insulin resistance of HIV disease. Chromium supplements will be given daily over a 4 month course of treatment and the insulin sensitivity will be determined at baseline and after 2 and 4 months of therapy. Possible toxicity will be monitored every 2 weeks. This pilot data will be used as preliminary data for a larger study on the mechanism by which chromium improves insulin sensitivity.