POST-PRANDIAL LIPEMIA IN OBESE COMPARED TO LEAN CHILDREN

肥胖儿童与瘦儿童餐后脂血症的比较

• 批准号: 7374381
• 负责人: TRACY J HORTON
• 金额: $ 5.45万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374381
• 关键词: children; exercise; health; lipids; obesity; triglycerides

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to better understand the role of obesity and exercise in cardiovascular health in children. As the atherosclerotic process can begin early in life, it is crucial to understand factors that can significantly impact this process. In adults, elevated post-prandial triglycerides (TGs) are an independent risk factor for coronary heart disease, and increased post-meal lipoprotein-derived remnant-like particles (RLP) are particularly atherogenic. Obesity in adults exacerbates post-prandial lipemia whereas exercise ameliorates this. Studies in this application will determine if this is also true in children. The post-prandial lipid response to a moderately high fat meal will be compared in obese and lean children over a 6 hr period with blood sampled every hour. Assessments will be conducted in the morning on two occasions; after a moderate exercise bout the afternoon before, and after no exercise. Primary outcomes will include post-prandial TGs, triglyceride-rich lipoprotein subfractions and associated RLP levels. Secondary outcomes will include circulating changes in cholesterol, apolipoprotein B, insulin, glucose, free-fatty acid, glycerol, and whole-body lipid oxidation. This study will provide preliminary data to more comprehensively assess factors that may impact cardiovascular health in childhood, including diabetes and ethnicity, and interventions that may improve this, such as chronic exercise alone or wi

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。我们的目标是更好地了解肥胖和运动在儿童心血管健康中的作用。由于动脉粥样硬化过程可以在生命早期开始，因此了解可以显著影响该过程的因素至关重要。在成人中，餐后甘油三酯（TG）升高是冠心病的独立危险因素，餐后脂蛋白衍生的残粒样颗粒（RLP）增加尤其易致动脉粥样硬化。成年人肥胖会加重餐后脂血症，而运动可以改善这种情况。本申请中的研究将确定这是否也适用于儿童。将在6小时内比较肥胖和消瘦儿童对中等高脂肪膳食的餐后脂质反应，每小时采集一次血样。评估将在上午进行两次;前一天下午适度运动后和不运动后。主要结果将包括餐后TG、富含甘油三酯的脂蛋白亚组分和相关RLP水平。次要结局将包括胆固醇、载脂蛋白B、胰岛素、葡萄糖、游离脂肪酸、甘油和全身脂质氧化的循环变化。这项研究将提供初步数据，以更全面地评估可能影响儿童心血管健康的因素，包括糖尿病和种族，以及可能改善这一点的干预措施，如单独或长期运动，