POST-PRANDIAL LIPEMIA IN OBESE COMPARED TO LEAN CHILDREN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们的目标是更好地了解肥胖和运动对儿童心血管健康的作用。由于动脉粥样硬化过程可以在生命的早期就开始，因此了解可能显著影响这一过程的因素是至关重要的。在成年人中，餐后甘油三酯(TGS)升高是冠心病的独立危险因素，而餐后脂蛋白衍生残留物样颗粒(RLP)增加尤其会导致动脉粥样硬化。成年人的肥胖会加剧餐后血脂，而运动可以改善这种情况。本应用程序中的研究将确定这是否也适用于儿童。研究人员将比较肥胖儿童和瘦儿童在6小时内对中等脂肪饮食的餐后血脂反应，并每小时抽血一次。评估将在两种情况下在上午进行：前一天下午适度运动后，以及不运动后。主要结果将包括餐后TGS、富含甘油三酯的脂蛋白亚组分和相关的RLP水平。次要结果将包括胆固醇、载脂蛋白B、胰岛素、血糖、游离脂肪酸、甘油和全身脂质氧化的循环变化。这项研究将提供初步数据，以更全面地评估可能影响儿童心血管健康的因素，包括糖尿病和种族，以及可能改善这一状况的干预措施，如单独或长期锻炼

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to better understand the role of obesity and exercise in cardiovascular health in children. As the atherosclerotic process can begin early in life, it is crucial to understand factors that can significantly impact this process. In adults, elevated post-prandial triglycerides (TGs) are an independent risk factor for coronary heart disease, and increased post-meal lipoprotein-derived remnant-like particles (RLP) are particularly atherogenic. Obesity in adults exacerbates post-prandial lipemia whereas exercise ameliorates this. Studies in this application will determine if this is also true in children. The post-prandial lipid response to a moderately high fat meal will be compared in obese and lean children over a 6 hr period with blood sampled every hour. Assessments will be conducted in the morning on two occasions; after a moderate exercise bout the afternoon before, and after no exercise. Primary outcomes will include post-prandial TGs, triglyceride-rich lipoprotein subfractions and associated RLP levels. Secondary outcomes will include circulating changes in cholesterol, apolipoprotein B, insulin, glucose, free-fatty acid, glycerol, and whole-body lipid oxidation. This study will provide preliminary data to more comprehensively assess factors that may impact cardiovascular health in childhood, including diabetes and ethnicity, and interventions that may improve this, such as chronic exercise alone or wi