SEX-BASED COMPARISION OF THE ADRENERGIC REGULATION OF SUBSTRATE METABOLISM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 男性和女性在身体优先使用脂肪和碳水化合物作为燃料来源的方式上有所不同。这尤其是在身体能量需求和/或葡萄糖需求增加的情况下。其中一个例子是在锻炼过程中。燃料利用模式中这些基于性别的差异是如何实现的尚不清楚。两种重要的激素，参与动员脂肪和碳水化合物从身体储存是肾上腺素和去甲肾上腺素（称为儿茶酚胺）。 一旦动员，脂肪或碳水化合物可以用作燃料。与男性相比，女性似乎能够更好地调动脂肪来应对这些激素。因此，这项研究将更详细地研究这些脂质动员激素中的一种是如何增加女性脂肪释放的。这将需要低水平的激素和/或模拟或停止脂质动员激素的一些作用的类脂质化合物输注到手臂静脉中。为了观察多少脂肪与多少葡萄糖响应于这些激素/类激素化合物而被动员，将脂肪和葡萄糖的天然存在的示踪剂输注到同一手臂静脉中。将从手静脉中采集血液样本，以观察血液中这些示踪剂的水平以及激素、脂肪和葡萄糖代谢产物的水平。为了抽取血液样本，手在温暖的盒子里加热。 在整个研究过程中还将收集呼吸样本，以观察有多少脂肪和碳水化合物被动员起来用作燃料。这项研究的结果将有助于我们更好地了解男性和女性如何不同地控制燃料使用。因此，将获得重要的信息，以更好地帮助我们了解肥胖和糖尿病等疾病，这些疾病可能存在葡萄糖和脂质利用异常。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Men and women differ in the way their bodies prioritize the use of fat and carbohydrate as fuel sources. This is seen particularly in response to situations where there is an increase in the body s energy requirements, and/or glucose requirements. An example of this is during exercise. How these sex-based differences in the pattern of fuel utilization are achieved is not known. Two important hormones that are involved in mobilizing fat and carbohydrate from the bodies stores are epinephrine and norepinephrine (called catecholamines). Once mobilized, the fat or carbohydrate can be used as a fuel. Women appear to be better able to mobilize fat in response to these hormones compared to men. This study will, therefore, look in more detail at how exactly one of these lipid mobilizing hormones increase fat release more in women than men. This will require a low level infusion of the hormone, and/or hormone-like compounds that either mimic or stop some of the effects of the lipid-mobilizing hormone, into an arm vein. To look at how much fat versus how much glucose is mobilized in response to these hormone/hormone-like compounds, infusions will be made into the same arm vein of naturally occurring tracers of fat and glucose. Blood samples will be taken from a hand vein to look at the levels of these tracers in the blood as well as levels of hormones and fat and glucose metabolites. To draw blood samples, the hand is heated in a warm box. Breath samples will also be collected throughout the study to look at how much of the fat and carbohydrate that is mobilized is used as a fuel. Results from this study will help us to gain a better understanding of how fuel use is controlled differently in men and women. Thus, important information will be gained to better help us understand conditions such as obesity and diabetes where there can be abnormalities in glucose and lipid utilization.