THE EFFECT OF ACUTE EXERCISE ON POST-PRANDIAL LIPEMIA

剧烈运动对餐后脂血症的影响

• 批准号: 7377799
• 负责人: TRACY J HORTON
• 金额: $ 12.78万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377799
• 关键词: EFFECT; ACUTE; EXERCISE; POST; PRANDIAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regular physical exercise is beneficial in terms of the prevention and treatment of many diseases including coronary heart disease. An understanding of why exercise is so key in the maintenance of health requires a thorough understanding of it affects the body. One of the ways in which exercise may have cardiovascular benefits is through its favorable affects on the levels of fat and cholesterol in the blood. It has been shown that after a meal, the higher the level of fat and cholesterol there is in the blood, the more a person is at risk of developing heart disease. Hence, any intervention that can help lower the level of these two things will have health benefits. Interestingly, a single bout of exercise has been shown to lower the level of blood fat and cholesterol after a meal. However, this has only been looked at under limited conditions in specific type of people. For example it has only been measured after an extremely high fat meal, which is not normally what people eat. In addition, it has only been looked at after a single meal, and not over a whole day when more meals are eaten. For the most part, measurements have been made in young, lean healthy men with a very limited number of tests in women or in people with increased risk of heart disease, for example people who have high blood pressure and/or are overweight with body fat mainly located in the upper body. Information is important in all these groups to fully understand the health benefits of exercise. This study will, therefore, more comprehensively assess the ability of exercise to lower blood fat and cholesterol levels after meals eaten over a full day. In order to test this, a single, moderate exercise bout will be performed in the morning, and the levels of blood fat and cholesterol followed for the rest of the day after eating breakfast, lunch and dinner. For comparison purposes, the same testing will be done on a day when no exercise is performed. The studies will be done in men and women, both healthy individuals, and individuals who would be considered to be at increased risk of developing heart disease. In addition, the meals eaten on the two test days will have an amount of fat that is more typical of people's usual diet to make the results more applicable to real life. On each of the study days, a small sample of muscle and adipose tissue will be taken in the morning and in the afternoon to help identify things that may be help clear fat from the blood and so explain why exercise lowers blood fat and cholesterol after meals.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。经常锻炼身体有利于预防和治疗包括冠心病在内的多种疾病。要了解为什么运动对于维持健康如此重要，需要彻底了解它对身体的影响。运动对心血管有益的方式之一是通过其对血液中脂肪和胆固醇水平的有利影响。研究表明，饭后血液中的脂肪和胆固醇含量越高，患心脏病的风险就越大。因此，任何有助于降低这两件事水平的干预措施都会对健康有益。有趣的是，单次运动已被证明可以降低餐后血脂和胆固醇水平。然而，这只是在有限的条件下针对特定类型的人进行了研究。例如，它仅在食用极高脂肪的膳食后进行测量，而人们通常不吃这种食物。此外，只在一顿饭后进行观察，而在多餐时则不会观察一整天的情况。大多数情况下，测量都是在年轻、瘦弱的健康男性中进行的，而对女性或心脏病风险较高的人进行的测试数量非常有限，例如患有高血压和/或体重超标且身体脂肪主要位于上半身的人。对于所有这些群体来说，信息对于充分了解运动的健康益处都很重要。因此，这项研究将更全面地评估运动降低全天餐后血脂和胆固醇水平的能力。为了测试这一点，我们将在早上进行一次适度的运动，并在早餐、午餐和晚餐后的剩余时间内跟踪血脂和胆固醇水平。出于比较目的，将在不进行锻炼的一天进行相同的测试。这些研究将在男性和女性中进行，包括健康个体和被认为患心脏病风险增加的个体。此外，两个测试日所吃的膳食将含有更符合人们平时饮食的脂肪量，以使结果更适用于现实生活。在每个研究日，我们都会在早上和下午采集少量肌肉和脂肪组织样本，以帮助识别可能有助于清除血液中脂肪的物质，从​​而解释为什么运动可以降低餐后血脂和胆固醇。