THE EFFECT OF ACUTE EXERCISE ON POST-PRANDIAL LIPEMIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。经常锻炼身体对预防和治疗包括冠心病在内的许多疾病都是有益的。要理解为什么运动对保持健康如此重要，就需要彻底了解它对身体的影响。运动对心血管有益的一种方式是通过它对血液中脂肪和胆固醇水平的有利影响。研究表明，饭后，血液中的脂肪和胆固醇含量越高，患心脏病的风险就越大。因此，任何有助于降低这两种物质水平的干预措施都对健康有益。有趣的是，单次运动已被证明可以降低餐后的血脂和胆固醇水平。然而，这只是在有限的条件下对特定类型的人进行了研究。例如，它只在高脂肪餐后测量，而人们通常不吃高脂肪餐。此外，它只在一顿饭后进行研究，而不是在一天中多吃几顿饭后进行研究。在大多数情况下，测量对象是年轻、精瘦的健康男性，而对女性或心脏病风险较高的人群进行的测试数量非常有限，例如患有高血压和/或超重且体脂肪主要集中在上半身的人。在所有这些群体中，信息对于充分理解运动对健康的益处是很重要的。因此，这项研究将更全面地评估运动在降低一整天饭后血脂和胆固醇水平方面的能力。为了验证这一点，研究人员将在早上进行一次单一的、适度的运动，并在吃完早餐、午餐和晚餐后的一天剩余时间里追踪血脂和胆固醇的水平。为了比较，同样的测试将在没有运动的一天进行。这些研究将在男性和女性中进行，既有健康的人，也有被认为患心脏病风险较高的人。此外，在两个测试日所吃的食物中，脂肪的含量会更典型地反映人们的日常饮食，使结果更适用于现实生活。在每一天的研究中，研究人员将在上午和下午抽取一小块肌肉和脂肪组织样本，以帮助确定哪些东西可能有助于清除血液中的脂肪，从而解释为什么运动可以降低饭后的血脂和胆固醇。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regular physical exercise is beneficial in terms of the prevention and treatment of many diseases including coronary heart disease. An understanding of why exercise is so key in the maintenance of health requires a thorough understanding of it affects the body. One of the ways in which exercise may have cardiovascular benefits is through its favorable affects on the levels of fat and cholesterol in the blood. It has been shown that after a meal, the higher the level of fat and cholesterol there is in the blood, the more a person is at risk of developing heart disease. Hence, any intervention that can help lower the level of these two things will have health benefits. Interestingly, a single bout of exercise has been shown to lower the level of blood fat and cholesterol after a meal. However, this has only been looked at under limited conditions in specific type of people. For example it has only been measured after an extremely high fat meal, which is not normally what people eat. In addition, it has only been looked at after a single meal, and not over a whole day when more meals are eaten. For the most part, measurements have been made in young, lean healthy men with a very limited number of tests in women or in people with increased risk of heart disease, for example people who have high blood pressure and/or are overweight with body fat mainly located in the upper body. Information is important in all these groups to fully understand the health benefits of exercise. This study will, therefore, more comprehensively assess the ability of exercise to lower blood fat and cholesterol levels after meals eaten over a full day. In order to test this, a single, moderate exercise bout will be performed in the morning, and the levels of blood fat and cholesterol followed for the rest of the day after eating breakfast, lunch and dinner. For comparison purposes, the same testing will be done on a day when no exercise is performed. The studies will be done in men and women, both healthy individuals, and individuals who would be considered to be at increased risk of developing heart disease. In addition, the meals eaten on the two test days will have an amount of fat that is more typical of people's usual diet to make the results more applicable to real life. On each of the study days, a small sample of muscle and adipose tissue will be taken in the morning and in the afternoon to help identify things that may be help clear fat from the blood and so explain why exercise lowers blood fat and cholesterol after meals.