THE EFFECT OF ACUTE EXERCISE ON POST-PRANDIAL LIPEMIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 有规律的体育锻炼在预防和治疗包括冠心病在内的许多疾病方面是有益的。要理解为什么运动对保持健康如此关键，就必须彻底了解运动对身体的影响。运动可能对心血管有益的方式之一是通过它对血液中脂肪和胆固醇水平的有利影响。研究表明，饭后血液中的脂肪和胆固醇水平越高，一个人患心脏病的风险就越大。因此，任何有助于降低这两种物质水平的干预措施都将对健康有益。有趣的是，一次运动就能降低餐后的血脂和胆固醇水平。然而，这只在特定类型的人的有限条件下进行了研究。例如，只有在吃了极高脂肪的食物后才会测量它，而人们通常不吃这种食物。此外，它只在一顿饭之后被观察，而不是在一整天吃更多的食物时被观察到。在很大程度上，测量是在年轻、苗条、健康的男性中进行的，女性的测试次数非常有限，或者是心脏病风险增加的人，例如患有高血压和/或超重且体脂主要位于上半身的人。在所有这些群体中，信息都很重要，以充分了解锻炼对健康的好处。因此，这项研究将更全面地评估运动在全天进食后降低血脂和胆固醇水平的能力。为了测试这一点，早上将进行一次适度的运动，并在吃完早餐、午餐和晚餐后，在一天的其余时间里跟踪血脂和胆固醇的水平。为了进行比较，同样的测试将在不进行锻炼的那一天进行。这些研究将在男性和女性中进行，无论是健康的人，还是被认为患有心脏病风险增加的人。此外，在两个测试日吃的一餐将含有更典型的人们日常饮食中的脂肪量，使结果更适用于现实生活。在研究的每一天，上午和下午都会采集少量肌肉和脂肪组织样本，以帮助识别可能有助于从血液中清除脂肪的物质，从而解释为什么运动能在饭后降低血脂和胆固醇。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regular physical exercise is beneficial in terms of the prevention and treatment of many diseases including coronary heart disease. An understanding of why exercise is so key in the maintenance of health requires a thorough understanding of it affects the body. One of the ways in which exercise may have cardiovascular benefits is through its favorable affects on the levels of fat and cholesterol in the blood. It has been shown that after a meal, the higher the level of fat and cholesterol there is in the blood, the more a person is at risk of developing heart disease. Hence, any intervention that can help lower the level of these two things will have health benefits. Interestingly, a single bout of exercise has been shown to lower the level of blood fat and cholesterol after a meal. However, this has only been looked at under limited conditions in specific type of people. For example it has only been measured after an extremely high fat meal, which is not normally what people eat. In addition, it has only been looked at after a single meal, and not over a whole day when more meals are eaten. For the most part, measurements have been made in young, lean healthy men with a very limited number of tests in women or in people with increased risk of heart disease, for example people who have high blood pressure and/or are overweight with body fat mainly located in the upper body. Information is important in all these groups to fully understand the health benefits of exercise. This study will, therefore, more comprehensively assess the ability of exercise to lower blood fat and cholesterol levels after meals eaten over a full day. In order to test this, a single, moderate exercise bout will be performed in the morning, and the levels of blood fat and cholesterol followed for the rest of the day after eating breakfast, lunch and dinner. For comparison purposes, the same testing will be done on a day when no exercise is performed. The studies will be done in men and women, both healthy individuals, and individuals who would be considered to be at increased risk of developing heart disease. In addition, the meals eaten on the two test days will have an amount of fat that is more typical of people's usual diet to make the results more applicable to real life. On each of the study days, a small sample of muscle and adipose tissue will be taken in the morning and in the afternoon to help identify things that may be help clear fat from the blood and so explain why exercise lowers blood fat and cholesterol after meals.