THE EFFECT OF ACUTE EXERCISE ON POST-PRANDIAL LIPEMIA

剧烈运动对餐后脂血症的影响

• 批准号: 7604393
• 负责人: TRACY J HORTON
• 金额: $ 18.65万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604393
• 关键词: Acute; Adipose tissue; Affect; Blood; Body fat; Cardiovascular system; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Condition; Coronary heart disease; Diet; Disease; Eating; Exercise; Fatty acid glycerol esters; Funding; Grant; Health; Health Benefit; Heart Diseases; High Blood Pressure; Individual; Institution; Intervention; Life; Maintenance; Measurement; Measures; Moderate Exercise; Muscle; Numbers; Overweight; Persons; Prevention; Purpose; Research; Research Personnel; Resources; Rest; Risk; Sampling; Source; Testing; United States National Institutes of Health; Woman; day; heart disease risk; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regular physical exercise is beneficial in terms of the prevention and treatment of many diseases including coronary heart disease. An understanding of why exercise is so key in the maintenance of health requires a thorough understanding of it affects the body. One of the ways in which exercise may have cardiovascular benefits is through its favorable affects on the levels of fat and cholesterol in the blood. It has been shown that after a meal, the higher the level of fat and cholesterol there is in the blood, the more a person is at risk of developing heart disease. Hence, any intervention that can help lower the level of these two things will have health benefits. Interestingly, a single bout of exercise has been shown to lower the level of blood fat and cholesterol after a meal. However, this has only been looked at under limited conditions in specific type of people. For example it has only been measured after an extremely high fat meal, which is not normally what people eat. In addition, it has only been looked at after a single meal, and not over a whole day when more meals are eaten. For the most part, measurements have been made in young, lean healthy men with a very limited number of tests in women or in people with increased risk of heart disease, for example people who have high blood pressure and/or are overweight with body fat mainly located in the upper body. Information is important in all these groups to fully understand the health benefits of exercise. This study will, therefore, more comprehensively assess the ability of exercise to lower blood fat and cholesterol levels after meals eaten over a full day. In order to test this, a single, moderate exercise bout will be performed in the morning, and the levels of blood fat and cholesterol followed for the rest of the day after eating breakfast, lunch and dinner. For comparison purposes, the same testing will be done on a day when no exercise is performed. The studies will be done in men and women, both healthy individuals, and individuals who would be considered to be at increased risk of developing heart disease. In addition, the meals eaten on the two test days will have an amount of fat that is more typical of people's usual diet to make the results more applicable to real life. On each of the study days, a small sample of muscle and adipose tissue will be taken in the morning and in the afternoon to help identify things that may be help clear fat from the blood and so explain why exercise lowers blood fat and cholesterol after meals.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 定期体育锻炼在预防和治疗包括冠心病在内的许多疾病方面是有益的。 了解为什么运动在维持健康中如此关键需要对其进行彻底的了解会影响身体。 运动可能具有心血管益处的方式之一是对血液中脂肪和胆固醇水平的有利影响。 已经表明，一顿饭后，血液中脂肪和胆固醇的水平越高，一个人就有患心脏病的风险越多。 因此，任何可以帮助降低这两件事水平的干预措施都将带来健康益处。 有趣的是，一场运动已被证明可以降低饭后血脂和胆固醇的水平。 但是，这仅在特定类型的人的条件下才研究。 例如，它仅在脂肪含量极高后才进行测量，这通常不是人们吃的东西。 此外，只有一顿一顿饭才能在一顿一顿饭之后看到它。 在大多数情况下，在女性或患有心脏病风险增加的患者的年轻，苗条健康的男性中进行了测量，例如，患有高血压和/或超重的人，体内脂肪主要位于上半身。 在所有这些小组中，信息都很重要，以充分了解运动的健康益处。 因此，这项研究将更全面地评估运动在整天吃饭后降低血脂和胆固醇水平的能力。 为了测试这一点，将在早上进行一次，适度的运动，在吃早餐，午餐和晚餐后的剩余时间，血脂和胆固醇的水平随之而来。 为了进行比较，将在不进行运动的一天进行相同的测试。 这些研究将在男人和女人的健康中，以及被认为是患心脏病风险增加的个体。 此外，在两个测试日食用的餐点将有大量的脂肪，这是人们通常的饮食饮食更典型的脂肪，以使结果更适用于现实生活。 在每个研究日子里，一小部分肌肉和脂肪组织都将在早晨和下午进行，以帮助识别可能有助于清除血液中的脂肪的事物，因此解释为什么运动会在饭后降低血液脂肪和胆固醇。