THE EFFECT OF ACUTE EXERCISE ON POST-PRANDIAL LIPEMIA

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regular physical exercise is beneficial in terms of the prevention and treatment of many diseases including coronary heart disease. An understanding of why exercise is so key in the maintenance of health requires a thorough understanding of it affects the body. One of the ways in which exercise may have cardiovascular benefits is through its favorable affects on the levels of fat and cholesterol in the blood. It has been shown that after a meal, the higher the level of fat and cholesterol there is in the blood, the more a person is at risk of developing heart disease. Hence, any intervention that can help lower the level of these two things will have health benefits. Interestingly, a single bout of exercise has been shown to lower the level of blood fat and cholesterol after a meal. However, this has only been looked at under limited conditions in specific type of people. For example it has only been measured after an extremely high fat meal, which is not normally what people eat. In addition, it has only been looked at after a single meal, and not over a whole day when more meals are eaten. For the most part, measurements have been made in young, lean healthy men with a very limited number of tests in women or in people with increased risk of heart disease, for example people who have high blood pressure and/or are overweight with body fat mainly located in the upper body. Information is important in all these groups to fully understand the health benefits of exercise. This study will, therefore, more comprehensively assess the ability of exercise to lower blood fat and cholesterol levels after meals eaten over a full day. In order to test this, a single, moderate exercise bout will be performed in the morning, and the levels of blood fat and cholesterol followed for the rest of the day after eating breakfast, lunch and dinner. For comparison purposes, the same testing will be done on a day when no exercise is performed. The studies will be done in men and women, both healthy individuals, and individuals who would be considered to be at increased risk of developing heart disease. In addition, the meals eaten on the two test days will have an amount of fat that is more typical of people's usual diet to make the results more applicable to real life. On each of the study days, a small sample of muscle and adipose tissue will be taken in the morning and in the afternoon to help identify things that may be help clear fat from the blood and so explain why exercise lowers blood fat and cholesterol after meals.