POST-PRANDIAL LIPEMIA IN OBESE COMPARED TO LEAN CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的目标是更好地了解肥胖和种族在儿童心血管健康中的作用，并评估运动在这方面的潜在好处。在成年人中，肥胖会增加心血管疾病(CVD)的风险，西班牙裔种族也是如此。炎症和内皮损伤生物标志物水平升高与心血管疾病风险增加相关。此外，餐后甘油三酯(TGS)升高是成人冠心病(CHD)的独立危险因素，而餐后脂蛋白衍生残留物样颗粒(RLP)增加尤其导致动脉粥样硬化。目前尚不清楚这些因素在肥胖和/或西班牙裔儿童中是否会升高。在成年人中，锻炼在改善某些炎症标志物和降低餐后血脂方面是有益的。如果在高危儿童中是这样的话，这将支持在生命早期将锻炼作为一种预防工具。这项研究将确定炎症标志物和对中等高脂肪饮食的血脂反应是否因肥胖和/或种族而不同，以及急性运动是否有利于影响儿童的这些参数。将测量肥胖和消瘦、西班牙裔和高加索儿童的休息、运动后和餐后炎症标志物和循环血脂水平，并每小时采血一次。评估将在两种情况下进行；一次是在前一天下午进行适度运动之后，另一次是受试者在前一天久坐不动。主要观察指标：炎症和氧化应激标志物(C反应蛋白、IL-6、肿瘤坏死因子？、氧化低密度脂蛋白)，以及餐后TGS和RLP浓度。次要结果：胆固醇、胰岛素和葡萄糖的循环变化。这项研究将提供初步数据，以更好地评估从童年开始就影响心血管风险的因素，以及运动是否可以降低这种风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goals are to better understand the role of obesity and ethnicity in cardiovascular health in children and, assess the potential benefits of exercise in this regard. In adults, obesity increases risk of cardiovascular disease (CVD) as does Hispanic ethnicity. Elevated levels of inflammatory and endothelial damage biomarkers are associated with increased CVD risk. Furthermore, elevated post-prandial triglycerides (TGs) are independent risk factors for coronary heart disease (CHD) in adults, and increased post-meal lipoprotein-derived remnant-like particles (RLP) are particularly atherogenic. It is unknown whether these factors are elevated in obese and/or Hispanic children. In adults, exercise has been beneficial in improving certain markers of inflammation and diminishing post-prandial lipemia. If true in at-risk children, this would support exercise as a preventative tool early in life. This study will determine if inflammatory markers and the lipemic response to a moderately high fat meal differs by obesity and/or ethnicity, and if acute exercise favorably impacts these parameters in children. Resting, post-exercise and post-prandial levels of inflammatory markers and circulating blood lipids will be measured in obese and lean, Hispanic and Caucasian, children over 6 hrs with blood sampled hourly. Assessments will be conducted on two occasions; one following a moderate exercise bout the afternoon before, and one with subjects being sedentary the day prior. Primary outcome measures: inflammatory and oxidative stress markers (CRP, IL-6, TNF-?, ox-LDL), and post-prandial TGs and RLP concentrations. Secondary outcomes: circulating changes in cholesterol, insulin and glucose. This study will provide preliminary data to better assess factors impacting cardiovascular risk beginning in childhood, and if exercise may decrease this risk.