POST-PRANDIAL LIPEMIA IN OBESE COMPARED TO LEAN CHILDREN

肥胖儿童与瘦儿童餐后脂血症的比较

• 批准号: 7605099
• 负责人: TRACY J HORTON
• 金额: $ 3.54万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605099
• 关键词: Acute; Adult; Biological Markers; Blood specimen; Cardiovascular system; Caucasians; Caucasoid Race; Child; Childhood; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Data; Ethnic Origin; Exercise; Fatty acid glycerol esters; Funding; Glucose; Goals; Grant; Health; Hispanics; Inflammation; Inflammatory; Institution; Insulin; Interleukin-6; Life; Lipoproteins; Measures; Moderate Exercise; Obesity; Outcome; Outcome Measure; Oxidative Stress; Research; Research Personnel; Resources; Rest; Risk; Risk Factors; Role; Source; TNF gene; Triglycerides; United States National Institutes of Health; blood lipid; cardiovascular disorder risk; cardiovascular risk factor; cysteine rich protein; day; improved; oxidized low density lipoprotein; particle; response; sedentary; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goals are to better understand the role of obesity and ethnicity in cardiovascular health in children and, assess the potential benefits of exercise in this regard. In adults, obesity increases risk of cardiovascular disease (CVD) as does Hispanic ethnicity. Elevated levels of inflammatory and endothelial damage biomarkers are associated with increased CVD risk. Furthermore, elevated post-prandial triglycerides (TGs) are independent risk factors for coronary heart disease (CHD) in adults, and increased post-meal lipoprotein-derived remnant-like particles (RLP) are particularly atherogenic. It is unknown whether these factors are elevated in obese and/or Hispanic children. In adults, exercise has been beneficial in improving certain markers of inflammation and diminishing post-prandial lipemia. If true in at-risk children, this would support exercise as a preventative tool early in life. This study will determine if inflammatory markers and the lipemic response to a moderately high fat meal differs by obesity and/or ethnicity, and if acute exercise favorably impacts these parameters in children. Resting, post-exercise and post-prandial levels of inflammatory markers and circulating blood lipids will be measured in obese and lean, Hispanic and Caucasian, children over 6 hrs with blood sampled hourly. Assessments will be conducted on two occasions; one following a moderate exercise bout the afternoon before, and one with subjects being sedentary the day prior. Primary outcome measures: inflammatory and oxidative stress markers (CRP, IL-6, TNF-?, ox-LDL), and post-prandial TGs and RLP concentrations. Secondary outcomes: circulating changes in cholesterol, insulin and glucose. This study will provide preliminary data to better assess factors impacting cardiovascular risk beginning in childhood, and if exercise may decrease this risk.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的目标是更好地了解肥胖和种族在儿童心血管健康中的作用，并评估运动在这方面的潜在益处。在成年人中，肥胖会增加心血管疾病（CVD）的风险，西班牙裔也是如此。炎症和内皮损伤生物标志物水平升高与CVD风险增加相关。此外，餐后甘油三酯（TG）升高是成人冠心病（CHD）的独立危险因素，餐后脂蛋白衍生的残粒样颗粒（RLP）增加尤其易致动脉粥样硬化。目前尚不清楚这些因素是否在肥胖和/或西班牙裔儿童中升高。在成年人中，运动有益于改善某些炎症标志物和减少餐后脂血症。如果在高危儿童中是真的，这将支持运动作为生命早期的预防工具。这项研究将确定炎症标志物和对中等高脂肪餐的脂血反应是否因肥胖和/或种族而异，以及急性运动是否对儿童的这些参数产生有利影响。将在6小时内测量肥胖和消瘦、西班牙裔和高加索儿童的静息、运动后和餐后炎症标志物和循环血脂水平，每小时采集一次血样。将在两种情况下进行评估;一种是在前一天下午进行适度运动后进行，另一种是受试者在前一天久坐不动。主要结局指标：炎症和氧化应激标志物（CRP、IL-6、TNF-？、ox-LDL）和餐后TG和RLP浓度。次要结局：胆固醇、胰岛素和葡萄糖的循环变化。这项研究将提供初步数据，以更好地评估影响儿童期心血管风险的因素，以及运动是否可以降低这种风险。