MECHANISMS OF FOOD HYPERSENSITIVITY IN ATOPIC DERMATITIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。对特应性疾病高危新生儿的饮食预防研究，以及盲法食物挑战引起的皮肤症状和免疫变化的研究强烈表明，ige介导的FH在AD中起着重要的致病作用。本研究的目的是更准确地定义儿童特应性皮炎（AD）的食物超敏反应（FH）的自然历史和免疫致病机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies of dietary prophylaxis in newborns at high risk for atopic disease, and provocation of skin symptoms and immunologic changes by blinded food challenges strongly suggest a significant pathogenic role for IgE-mediated FH in AD. The purpose of this research is to more precisely define the natural history and immunopathogenic mechanisms of food hypersensitivity (FH) in children with atopic dermatitis (AD).