MECHANISMS OF FOOD HYPERSENSITIVITY IN ATOPIC DERMATITIS

特应性皮炎食物过敏的机制

• 批准号: 7380504
• 负责人: Hugh A Sampson
• 金额: $ 12.65万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380504
• 关键词: children; food; role; skin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies of dietary prophylaxis in newborns at high risk for atopic disease, and provocation of skin symptoms and immunologic changes by blinded food challenges strongly suggest a significant pathogenic role for IgE-mediated FH in AD. The purpose of this research is to more precisely define the natural history and immunopathogenic mechanisms of food hypersensitivity (FH) in children with atopic dermatitis (AD).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在过敏性疾病高危新生儿中进行的饮食预防研究，以及通过盲法食物激发引起的皮肤症状和免疫学变化的研究强烈表明IgE介导的FH在AD中具有重要的致病作用。本研究的目的是更准确地确定食物过敏（FH）的自然历史和免疫发病机制的儿童特应性皮炎（AD）。