EARLY DETECTION OF CORTICALVISUAL IMPAIRMENT IN INFANTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项前瞻性研究，研究对象是在露西尔·帕卡德儿童医院出生体重低于1500克的早产儿。本研究项目涉及人类婴儿视觉发展的研究，旨在：1)描述涉及物体和图案识别的视觉机制的发展；2)开发临床有用的视觉功能测试，可应用于非语言儿童患者；3)评估利用弥散张量定量脑磁共振成像（MRI）检测早产儿中枢性视觉障碍相关脑病变的能力。这是一项为期1年的初步研究，旨在确定视觉诱发电位（VEP）和MRI在预测早产儿视力结果方面的有效性。这些数据将用于支持NIH长期随访研究的拨款申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective study of preterm infants who are admitted to Lucile Packard Children's Hospital with a birth weight less than 1500 grams. This research project involves studies of visual development in human infants designed to: 1) describe the development of visual mechanisms involved in the recognition of objects and patterns; 2) develop clinically useful tests of visual function that can be applied in non-verbal pediatric patients; and 3) to assess the ability of quantitative brain magnetic resonance imaging (MRI) using diffusion tensor to detect brain lesions that are associated with central visual impairment in premature infants. This is a preliminary study that is being conducted for 1 yr to determine the effectiveness of the visual evoked potentials (VEP) and MRI in predicting visual outcome in preterm infants. This data will be used to support an NIH grant application for a long-term follow-up study.