EARLY DETECTION OF CORTICALVISUAL IMPAIRMENT IN INFANTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项针对Lucile Packard儿童医院出生体重低于1500克的早产儿的前瞻性研究。这项研究项目涉及对人类婴儿视觉发育的研究，旨在：1)描述与物体和模式识别有关的视觉机制的发展；2)开发可应用于非语言儿童患者的临床有用的视觉功能测试；以及3)评估使用扩散张量的定量脑磁共振成像(MRI)检测与早产儿中枢视觉障碍相关的脑损伤的能力。 这是一项为期一年的初步研究，旨在确定视觉诱发电位(VEP)和磁共振成像在预测早产儿视力结果方面的有效性。这些数据将用于支持美国国立卫生研究院长期跟踪研究的拨款申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective study of preterm infants who are admitted to Lucile Packard Children's Hospital with a birth weight less than 1500 grams. This research project involves studies of visual development in human infants designed to: 1) describe the development of visual mechanisms involved in the recognition of objects and patterns; 2) develop clinically useful tests of visual function that can be applied in non-verbal pediatric patients; and 3) to assess the ability of quantitative brain magnetic resonance imaging (MRI) using diffusion tensor to detect brain lesions that are associated with central visual impairment in premature infants. This is a preliminary study that is being conducted for 1 yr to determine the effectiveness of the visual evoked potentials (VEP) and MRI in predicting visual outcome in preterm infants. This data will be used to support an NIH grant application for a long-term follow-up study.