GENETIC BASIS OF ANDROGEN EXCESS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。多囊卵巢综合征(PCOS)是一种原因不明的女性慢性高雄激素血症(男性激素过多)综合征。这项研究包括确定多囊卵巢综合征及其变异体的可能遗传基础。该研究的具体目的是验证一种假说，即激活的5型17-羟基类固醇脱氢酶变种有助于女性的高雄激素血症，并且特定的表型与这些变种有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is a syndrome of unexplained chronic hyperandrogenism (excess male hormone) in females. This research consists of determining the possible genetic basis for PCOS and its variants. The specific aim is to test the hypothesis that activating variants of type 5 17¿-hydroxysteroid dehydrogenase contribute to hyperandrogenism in women and that a specific phenotype is associated with these variants.