GENETIC BASIS OF ANDROGEN EXCESS

雄激素过多的遗传基础

• 批准号: 7378602
• 负责人: ROBERT L ROSENFIELD
• 金额: $ 10.1万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378602
• 关键词: androgens; female; genetics; hydroxysteroid dehydrogenases; male; phenotype; polycystic ovary syndrome; syndrome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is a syndrome of unexplained chronic hyperandrogenism (excess male hormone) in females. This research consists of determining the possible genetic basis for PCOS and its variants. The specific aim is to test the hypothesis that activating variants of type 5 17¿-hydroxysteroid dehydrogenase contribute to hyperandrogenism in women and that a specific phenotype is associated with these variants.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。多囊卵巢综合症（PCOS）是一种女性不明原因的慢性雄激素过多症（雄性激素过多）的综合症。这项研究包括确定多囊卵巢综合征及其变体可能的遗传基础。 具体目的是检验以下假设：5 型 17β-羟基类固醇脱氢酶的激活变体会导致女性雄激素过多症，并且特定表型与这些变体相关。