GENETIC BASIS OF ANDROGEN EXCESS

雄激素过多的遗传基础

• 批准号: 7604741
• 负责人: ROBERT L ROSENFIELD
• 金额: $ 2.13万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604741
• 关键词: Adrenal Glands; Adult; Androgens; Child; Chronic; Complex; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic; Glucose tolerance test; Grant; Hyperandrogenism; Institution; Outcome Measure; Ovarian; Pelvis; Phenotype; Polycystic Ovary Syndrome; Research; Research Personnel; Resources; Source; Staging; Syndrome; Testing; Ultrasonography; United States National Institutes of Health; Variant; Weight; Woman; base; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome of unexplained chronic hyperandrogenism. It appears to arise as a complex trait with contributions from both heritable and non-heritable factors. This study is to test the hypothesis that activating variants of 17¿-HSD5 contribute to hyperandrogenism in women and that a specific phenotype is associated with these variants. This project compares hyperandrogenic children and adults with stage- and weight-matched healthy controls. Outcome measure include ovarian and adrenal function test, glucose tolerance test, and pelvic ultrasound parameters.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多囊卵巢综合征（PCOS）是一种原因不明的慢性高雄激素血症的异质性综合征。它似乎是一个复杂的性状，遗传和非遗传因素都有贡献。 本研究旨在验证17 <$-HSD 5的激活变体导致女性高雄激素血症以及特定表型与这些变体相关的假设。该项目将高雄激素儿童和成人与阶段和体重匹配的健康对照进行比较。 结果测量包括卵巢和肾上腺功能测试、葡萄糖耐量测试和盆腔超声参数。