The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence

雄激素在人类青春期杏仁核亚核发育中的作用

• 批准号: 9388088
• 负责人: Megan Marie Herting
• 金额: $ 9.69万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-18 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388088
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Amygdaloid structure; Androgen Receptor; Androgens; Animal Model; Animals; Behavior; Birds; Brain; CAG repeat; Castration; Cell Nucleus; Cereals; Childhood; Clinical; Complex; Data; Data Set; Databases; Development; Diffusion Magnetic Resonance Imaging; Expressed Sequence Tags; Female; Female Adolescents; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression Regulation; Genes; Genetic; Genetic Variation; Genotype; Goals; Growth; Health Sciences; Heterogeneity; Hormones; Human; Individual; Knowledge; Length; Life; Literature; Magnetic Resonance Imaging; Male Adolescents; Medial; Mediating; Methodology; Methods; Neurosciences; Neurosciences Research; Oregon; Pattern; Population; Process; Puberty; Reporting; Research; Research Personnel; Resolution; Role; Sampling; Sex Characteristics; Social Behavior; Structure; Techniques; Testosterone; Transactivation; Transcriptional Regulation; United States National Institutes of Health; Universities; base; boys; dimorphism; disorder risk; emotional behavior; girls; imaging genetics; improved; in vivo; interest; male; neurodevelopment; novel; receptor; receptor sensitivity; sex; sexual dimorphism; social

Abstract The human amy ygdala is a c in structure made up of a number of nuclei, which together are vital for complex brai an array of emo 18-23 otional and s viors that con evelop across adolescence. While a number social behav ntinue to de of structural MR ave examined sex differe mygdala maturation, these studies have reported RI studies ha ences in am mixed findings.12-17 Moreove tudies sugge cific and heterogeneous effects of testosterone er, animal st est sex-spec on the developm of var subnuclei within the amygdala.8-10 However, confirming similar patterns o ment rious r of growth in humans has been n limited by the inability ly segment amygdala subnuclei in adolescents y to precisel using MRI. Using a large NIH-funded im etic, and hormone adolescent dataset (N=450; ages 10-18 maging, gen yrs.; PI: Nagel), the current proposal aim ms to adapt a new in vivo amygdala segmentation approach to assess structural segme entation of amygdala s cross adolescence. Following individually based subnuclei subnuclei ac delineation, we a determine ho rone levels and androgen receptor (AR) sensitivity relates to also aim to d ow testoster neurotypic amy subn volum in adolescent oys and girls. Elucidating struc sexua ygdala nuclei mes bo g tural al dimorphisms in amygdala s humans ma ur understanding of amygdala development, as subnuclei in ay aid in ou well as ultimately help us to understan sex differences in various behaviors and risk for disease.7 nd life-long s Moreover, this r research wil ly contribute ger field of developmental neuroscience, as the ll significantl e to the larg current study ai date a meth process by which we can segment amygdala subnuclei in ims to elucid hodological p developing samp methods sh eful to a wide array of researchers who may wish to create ples. These hould be use specific normativ inical pediatr s for future structural, functional, and diffusion MRI studies. ve and/or cli ric templates

摘要 人类艾米 ygdala是一个c结构，由许多核组成，这些核在一起对 复杂脑 emo的数组18-23 在整个青春期都会发生的情感和暴力。虽然一些 社会责任继续进行 这些研究报道， 国际扶轮研究在上午的作用 混合的发现。12 -17更多的研究表明，睾酮的作用是特异性的， 动物测试性别鉴定 对杏仁核内各种亚核发育的影响。8 -10然而， 最后一次 人类的成长 n受限于青少年无法分割杏仁核亚核 y to precise 使用MRI。使用NIH资助的大型imetic和激素青少年数据集（N=450;年龄10-18 马金将军 yrs.; PI：内格尔），目前的提案目标是 ms采用新的体内杏仁核分割方法来评估 结构段 杏仁核的跨青春期效应。以下是基于个体的亚核 AC亚核 描绘，我们确定激素水平和雄激素受体（AR）敏感性与 我还打算去看看testoster 青春期男女的神经型艾米亚体积。解释性结构 颞叶外侧核 杏仁核的二型性人类破坏了我们对杏仁核发育的理解， 亚原子核 并最终帮助我们理解各种行为和疾病风险的性别差异。 终寿命 此外，R 研究将有助于发展神经科学领域，如 对大部分人来说都很重要 目前的研究是一种方法，我们可以分割杏仁核亚核， ims用于阐明hodological p 开发samp方法对希望创造出 请。这些应该是用 为将来的结构、功能和弥散MRI研究提供特定的正常临床儿科。 ve和/或模板