The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence

雄激素在人类青春期杏仁核亚核发育中的作用

• 批准号: 9388088
• 负责人: Megan Marie Herting
• 金额: $ 9.69万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-18 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388088
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Amygdaloid structure; Androgen Receptor; Androgens; Animal Model; Animals; Behavior; Birds; Brain; CAG repeat; Castration; Cell Nucleus; Cereals; Childhood; Clinical; Complex; Data; Data Set; Databases; Development; Diffusion Magnetic Resonance Imaging; Expressed Sequence Tags; Female; Female Adolescents; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression Regulation; Genes; Genetic; Genetic Variation; Genotype; Goals; Growth; Health Sciences; Heterogeneity; Hormones; Human; Individual; Knowledge; Length; Life; Literature; Magnetic Resonance Imaging; Male Adolescents; Medial; Mediating; Methodology; Methods; Neurosciences; Neurosciences Research; Oregon; Pattern; Population; Process; Puberty; Reporting; Research; Research Personnel; Resolution; Role; Sampling; Sex Characteristics; Social Behavior; Structure; Techniques; Testosterone; Transactivation; Transcriptional Regulation; United States National Institutes of Health; Universities; base; boys; dimorphism; disorder risk; emotional behavior; girls; imaging genetics; improved; in vivo; interest; male; neurodevelopment; novel; receptor; receptor sensitivity; sex; sexual dimorphism; social

Abstract The human amy ygdala is a c in structure made up of a number of nuclei, which together are vital for complex brai an array of emo 18-23 otional and s viors that con evelop across adolescence. While a number social behav ntinue to de of structural MR ave examined sex differe mygdala maturation, these studies have reported RI studies ha ences in am mixed findings.12-17 Moreove tudies sugge cific and heterogeneous effects of testosterone er, animal st est sex-spec on the developm of var subnuclei within the amygdala.8-10 However, confirming similar patterns o ment rious r of growth in humans has been n limited by the inability ly segment amygdala subnuclei in adolescents y to precisel using MRI. Using a large NIH-funded im etic, and hormone adolescent dataset (N=450; ages 10-18 maging, gen yrs.; PI: Nagel), the current proposal aim ms to adapt a new in vivo amygdala segmentation approach to assess structural segme entation of amygdala s cross adolescence. Following individually based subnuclei subnuclei ac delineation, we a determine ho rone levels and androgen receptor (AR) sensitivity relates to also aim to d ow testoster neurotypic amy subn volum in adolescent oys and girls. Elucidating struc sexua ygdala nuclei mes bo g tural al dimorphisms in amygdala s humans ma ur understanding of amygdala development, as subnuclei in ay aid in ou well as ultimately help us to understan sex differences in various behaviors and risk for disease.7 nd life-long s Moreover, this r research wil ly contribute ger field of developmental neuroscience, as the ll significantl e to the larg current study ai date a meth process by which we can segment amygdala subnuclei in ims to elucid hodological p developing samp methods sh eful to a wide array of researchers who may wish to create ples. These hould be use specific normativ inical pediatr s for future structural, functional, and diffusion MRI studies. ve and/or cli ric templates

抽象的 人类艾米 ygdala 是一个由许多原子核组成的 c 结构，这些原子核一起对于生命至关重要 复杂的脑 一系列 emo 18-23 贯穿青春期的观念和价值观。虽然有一个数 社会行为继续 结构 MR 检查的性别不同，杏仁核的成熟程度不同，这些研究报告 RI 研究 am 的影响 混合结果。12-17 更多研究表明睾酮的具体和异质性影响 呃，动物是性别规范 杏仁核内 var 亚核的发育。8-10 然而，证实了类似的模式 注意到 人类的成长已经 n 受限于青少年无法分割杏仁核亚核 y 到精确值 使用核磁共振成像。使用 NIH 资助的大型青少年激素数据集（N=450；年龄 10-18 岁） 成像、生成 年； PI：Nagel），当前提案目标 MS 采用新的体内杏仁核分割方法来评估 结构段 青春期杏仁核交叉的内陷。遵循单独的亚核 亚核ac 描述，我们确定激素水平和雄激素受体（AR）敏感性相关 也旨在提高睾丸水平 青少年男孩和女孩的神经型艾米·苏本卷。阐明性结构 ygdala 核 mes bo g tural al 人类杏仁核的二态性影响了我们对杏仁核发育的理解， ay 中的亚核 ou 中的辅助 并最终帮助我们了解各种行为和疾病风险的性别差异。7 并终生 而且，这个r 研究将为发育神经科学领域做出贡献 ll 显着地大 当前的研究人工智能确定了一种方法，我们可以通过该方法分割杏仁核亚核 ims 阐明方法学 p 开发样本方法对于许多希望创建的研究人员来说是困难的 请。这些应该会用到 为未来的结构、功能和扩散 MRI 研究提供特定的儿科规范。 ve 和/或 cli ric 模板