The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence

雄激素在人类青春期杏仁核亚核发育中的作用

• 批准号: 9388088
• 负责人: Megan Marie Herting
• 金额: $ 9.69万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-18 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388088
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Amygdaloid structure; Androgen Receptor; Androgens; Animal Model; Animals; Behavior; Birds; Brain; CAG repeat; Castration; Cell Nucleus; Cereals; Childhood; Clinical; Complex; Data; Data Set; Databases; Development; Diffusion Magnetic Resonance Imaging; Expressed Sequence Tags; Female; Female Adolescents; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression Regulation; Genes; Genetic; Genetic Variation; Genotype; Goals; Growth; Health Sciences; Heterogeneity; Hormones; Human; Individual; Knowledge; Length; Life; Literature; Magnetic Resonance Imaging; Male Adolescents; Medial; Mediating; Methodology; Methods; Neurosciences; Neurosciences Research; Oregon; Pattern; Population; Process; Puberty; Reporting; Research; Research Personnel; Resolution; Role; Sampling; Sex Characteristics; Social Behavior; Structure; Techniques; Testosterone; Transactivation; Transcriptional Regulation; United States National Institutes of Health; Universities; base; boys; dimorphism; disorder risk; emotional behavior; girls; imaging genetics; improved; in vivo; interest; male; neurodevelopment; novel; receptor; receptor sensitivity; sex; sexual dimorphism; social

Abstract The human amy ygdala is a c in structure made up of a number of nuclei, which together are vital for complex brai an array of emo 18-23 otional and s viors that con evelop across adolescence. While a number social behav ntinue to de of structural MR ave examined sex differe mygdala maturation, these studies have reported RI studies ha ences in am mixed findings.12-17 Moreove tudies sugge cific and heterogeneous effects of testosterone er, animal st est sex-spec on the developm of var subnuclei within the amygdala.8-10 However, confirming similar patterns o ment rious r of growth in humans has been n limited by the inability ly segment amygdala subnuclei in adolescents y to precisel using MRI. Using a large NIH-funded im etic, and hormone adolescent dataset (N=450; ages 10-18 maging, gen yrs.; PI: Nagel), the current proposal aim ms to adapt a new in vivo amygdala segmentation approach to assess structural segme entation of amygdala s cross adolescence. Following individually based subnuclei subnuclei ac delineation, we a determine ho rone levels and androgen receptor (AR) sensitivity relates to also aim to d ow testoster neurotypic amy subn volum in adolescent oys and girls. Elucidating struc sexua ygdala nuclei mes bo g tural al dimorphisms in amygdala s humans ma ur understanding of amygdala development, as subnuclei in ay aid in ou well as ultimately help us to understan sex differences in various behaviors and risk for disease.7 nd life-long s Moreover, this r research wil ly contribute ger field of developmental neuroscience, as the ll significantl e to the larg current study ai date a meth process by which we can segment amygdala subnuclei in ims to elucid hodological p developing samp methods sh eful to a wide array of researchers who may wish to create ples. These hould be use specific normativ inical pediatr s for future structural, functional, and diffusion MRI studies. ve and/or cli ric templates

摘要 人类艾米 Ygdala是由许多原子核组成的cin结构，这些原子核一起对 复杂的大脑 一组EMO 18-23 Otic和S的故事贯穿了整个青春期。而一个数字 社会行为要持续下去 这些研究报告说，结构磁共振检查了不同性别的Mygdala成熟。 国际扶轮在上午学习汉斯 混合发现。12-17更多的睾丸激素的科学和异质性的影响 呃，最具性别特征的动物 关于杏仁核内var亚核的发育，8-10证实了类似的模式 所有的人都知道 人类的成长一直是 N受青少年杏仁核亚核不能分割的限制 Y到精度 使用核磁共振。使用由NIH资助的大型免疫和荷尔蒙青少年数据集(N=450；年龄10-18岁 Maging，Gen 年；PI：Nagel)，当前的提案目标 MS将采用一种新的体内杏仁核分割方法来评估 结构段 S杏仁核纹状体进入青春期。以下是以个体为基础的亚核 亚核Ac 描述，我们确定激素水平与雄激素受体(AR)敏感性有关 还有一个目标是让Dow测试员 青春期青少年和女孩的神经型艾米体积。解说性结构 延髓核团 杏仁核二态S人类对杏仁核发育的更多理解，如 亚核在我们体内起到了辅助作用 并最终帮助我们了解不同行为的性别差异和患病风险 和终生S 此外，这份报告还包括 研究将为发展神经科学的更大领域做出贡献，因为 对于大人物来说，这是非常重要的 目前的研究表明，我们可以通过一种冰毒过程将杏仁核亚核分割成 IMS到Elucid Hodology p 开发SAMP方法对希望创建 普莱斯。这些应该被用来 未来结构、功能和弥散磁共振研究的特殊标准儿科医生S。 VE和/或临床模板