LH/FSH/INSULIN INTERACTIONS IN PCOS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们将检验一个特定的候选激活17 <$-HSD 5基因变体（G-138）或其他潜在的17 <$-HSD 5激活变体与细胞因子相互作用影响正常和PCOS患者卵巢睾酮分泌的假设。该研究包括吡格列酮和长效亮丙瑞林连续3-4个月疗程对促卵泡激素（FSH）预激前后卵巢对人绒毛膜促性腺激素（hCG）刺激反应的影响。 研究健康成年志愿者以建立对hCG <$FSH测试的正常反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will test the hypothesis that a specific candidate activating 17¿-HSD5 gene variant (G-138), or other potential 17¿-HSD5 activating variants, interacts with the cellular factors to affect ovarian testosterone secretion in both normal and PCOS patients. The study includes study of the effect of successive 3-4 month courses of pioglitazone and depot leuprolide on the ovarian response to human chorionic gonadotropin (hCG) stimulation before and after follicle stimulating hormone (FSH) priming. Healthy adult volunteers are studied to establish normal responses to hCG ¿ FSH testing.