INTERACTIONS IN PCOS

多囊卵巢综合症的相互作用

• 批准号: 7378619
• 负责人: ROBERT L ROSENFIELD
• 金额: $ 6.87万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378619
• 关键词: gonadotropins; granulosa cell; insulin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aim is to test the hypothesis that the phenotype of an activating variant of the 17b-HSD5 gene depends on interactions with LH, insulin resistant hyperinsulinemia, and FSH dependent granulosa cell factors. We will begin by determining the testosterone response to the LH analog human chronic gonadotropin (hCG) in PCOS and control women of known 17b-HSD5 genotype. Then we will determine the effects of suppressing gonadotropins with a GnRH agonist, suppressing insulin with a thiazolidinedione (TZD), and stimulating granulosa cell function with FSH. The effects of suppressing insulin with a TZD on LH pulse characteristics and indexes of insulin secretion/sensitivity will also be assessed.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。具体目的是检验17 b-HSD 5基因的活化变体的表型取决于与LH、胰岛素抵抗性高胰岛素血症和FSH依赖性颗粒细胞因子的相互作用的假设。我们将开始通过确定PCOS和已知17 b-HSD 5基因型的对照妇女的睾酮对LH类似物人慢性促性腺激素（hCG）的反应。然后，我们将确定用GnRH激动剂抑制促性腺激素，用噻唑烷二酮（TZD）抑制胰岛素，用FSH刺激颗粒细胞功能的效果。还将评估TZD抑制胰岛素对LH脉冲特征和胰岛素分泌/敏感性指数的影响。