GENETIC STUDIES OF CRANIOFACIAL AND LIMB DISORDERS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这一建议的总体假设是，遗传和环境因素参与了人类正常的颅面和肢体发育，是相关疾病的危险因素。这项建议的目标是确定那些与人类颅面和肢体发育有关的遗传和环境因素。在接下来的五年里，将在500多名患者中研究颅缝融合、口腔裂和下颌面部发育不良等常见的人类头面部疾病及其相关的肢体异常。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis of this proposal is that genetic and environmental factors are involved in normal human craniofacial and limb development and are risk factors for related disorders. The goal of this proposal is to determine those genetic and environmental factors involved in human craniofacial and limb development. The common human craniofacial conditions of craniosynostosis, oral clefts, and mandibulofacial dysostosis, and their associated limb abnormalities will be studied in over 500 patients during the next five year period.