GENETIC STUDIES OF CRANIOFACIAL AND LIMB DISORDERS

颅面和肢体疾病的遗传学研究

• 批准号: 7378757
• 负责人: Ethylin Wang Jabs
• 金额: $ 0.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378757
• 关键词: GENETIC; STUDIES; CRANIOFACIAL; LIMB; DISORDERS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis of this proposal is that genetic and environmental factors are involved in normal human craniofacial and limb development and are risk factors for related disorders. The goal of this proposal is to determine those genetic and environmental factors involved in human craniofacial and limb development. The common human craniofacial conditions of craniosynostosis, oral clefts, and mandibulofacial dysostosis, and their associated limb abnormalities will be studied in over 500 patients during the next five year period.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项建议的总体假设是，遗传和环境因素参与正常的人类颅面和肢体发育，是相关疾病的危险因素。这项研究的目的是确定人类颅面和肢体发育中的遗传和环境因素。在接下来的五年时间里，将对500多名患者进行研究，以了解常见的人类颅面条件，如颅缝早闭、口裂和下颌骨面骨发育不全及其相关的肢体异常。