Interdisciplinary Training in Systems and Developmental Biology and Birth Defects

摘要 系统生物学是一门相对较新的学科，用于理解健康背后的复杂相互作用。 细胞、组织或有机体的疾病状态，需要过程和分子网络的知识， 以及细胞、器官和整个生物体内部和之间的蛋白质相互作用。正常的研究 发育和出生缺陷是更成熟的经典学科。生物系统的整合 研究正常发育和先天发育缺陷的方法正在出现。的科学家 需要精通数学和生物学的人来解决发育生物学的复杂性， 研究成千上万的因素和事件，同时发生在一个时空和 在生物体的生命周期中定量的方式。因此，为了促进这些学科的交叉培训，我们 正在提交竞争性续约申请，以继续综合培训计划，“跨学科 伊坎医学院的系统和发育生物学与出生缺陷培训 纽约市的西奈山。在过去的四年零一个月里，我们成功地建立了一个项目， 包括来自8个不同部门，4个研究所和4个多学科培训领域的35名教师 （发育和再生生物学，神经科学，遗传学和基因组学，生物物理学） 和系统药理学）。一位杰出 一组具有系统生物学、发育生物学或出生缺陷专门知识的教育工作者和科学家， 包括外部咨询，执行学院和课程委员会的董事和成员， 为该计划提供领导、管理和指导。课程强调 整合了发育生物学、先天发育缺陷、基因组学、分子生物学、 生物化学、生理学、药理学、定量推理、计算生物学和生物信息学。我们 创建了新颖的课程，期刊俱乐部，和研讨会系列结合系统生物学的原则， 发育生物学和出生缺陷，以加强独特的学习经验。体制 承诺和加强多样性的基础设施;选择潜在的候选人;征聘; 设施和资源;负责任地开展研究和提高再现性的培训;支持 职业发展和培训方案评估已经存在。到目前为止， 我们已经支持了13名博士或MD/博士候选人1至2年的培训补助金; 3名学员已经离开了 接受他们的个人NIH F30或31奖项，3名学员已经毕业，并被接受到 优秀的博士后培养计划。我们的博士预科课程提供令人兴奋和独特的机会 从基因组和蛋白质到细胞、动物模型和人类的研究。的 这种创新培训的继续无疑将培养出急需的、处于前沿的科学家 计算生物学和发育生物学。

ABSTRACT Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal development and birth defects are more established classical disciplines. The integration of systems biologic approaches to the study of normal development and inborn errors of development is emerging. Scientists who are versed in both mathematics and biology are needed to address the complexities of development biology by examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and quantitative manner during the lifetime of an organism. Thus, to promote cross-training in these disciplines, we are submitting a competitive renewal application to continue the integrated training program, “Interdisciplinary Training in Systems and Developmental Biology and Birth Defects” at the Icahn School of Medicine at Mount Sinai in New York City. During the past four years and one month, we successfully built a program that includes 35 faculty members from 8 different departments, 4 institutes, and 4 multidisciplinary training areas (Developmental and Regenerative Biology, Neurosciences, Genetics and Genomics Sciences, and Biophysics and Systems Pharmacology) of the Graduate School of Biological Sciences at Mount Sinai. An outstanding group of educators and scientists with expertise in systems biology, developmental biology or birth defects, including the Directors and members of the External Advisory, Executive Faculty, and Curriculum Committees, provide the leadership, administration, and mentorship for the program. The Curriculum emphasizes the integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology, biochemistry, physiology, pharmacology, quantitative reasoning, computational biology, and bioinformatics. We have created novel courses, journal clubs, and seminar series combining principles of systems biology, developmental biology and birth defects in order to enhance the unique learning experience. The institutional infrastructure for commitment and enhancement of diversity; selection of potential candidates; recruitment; facilities and resources; training in responsible conduct of research and enhancing reproducibility; support for career development; and training program evaluations are already existent for this training program. To date, we have supported 13 PhD or MD/PhD candidates for 1 to 2 years on this training grant; 3 trainees have gone on to receive their individual NIH F30 or 31 awards, and 3 trainees have graduated and are accepted into excellent postdoctoral training programs. Our predoctoral program provides exciting and unique opportunities for study from genomes and proteins to cells, animal models, and humans at the bench and the bedside. The continuation of this innovative training will undoubtedly produce much needed scientists poised at the frontiers of both computational and developmental biology.