Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
基本信息
- 批准号:9751946
- 负责人:
- 金额:$ 18.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
ABSTRACT
Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy
and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular
and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal
development and birth defects are more established classical disciplines. The integration of systems biologic
approaches to the study of normal development and inborn errors of development is emerging. Scientists who
are versed in both mathematics and biology are needed to address the complexities of development biology by
examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and
quantitative manner during the lifetime of an organism. Thus, to promote cross-training in these disciplines, we
are submitting a competitive renewal application to continue the integrated training program, “Interdisciplinary
Training in Systems and Developmental Biology and Birth Defects” at the Icahn School of Medicine at
Mount Sinai in New York City. During the past four years and one month, we successfully built a program that
includes 35 faculty members from 8 different departments, 4 institutes, and 4 multidisciplinary training areas
(Developmental and Regenerative Biology, Neurosciences, Genetics and Genomics Sciences, and Biophysics
and Systems Pharmacology) of the Graduate School of Biological Sciences at Mount Sinai. An outstanding
group of educators and scientists with expertise in systems biology, developmental biology or birth defects,
including the Directors and members of the External Advisory, Executive Faculty, and Curriculum Committees,
provide the leadership, administration, and mentorship for the program. The Curriculum emphasizes the
integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology,
biochemistry, physiology, pharmacology, quantitative reasoning, computational biology, and bioinformatics. We
have created novel courses, journal clubs, and seminar series combining principles of systems biology,
developmental biology and birth defects in order to enhance the unique learning experience. The institutional
infrastructure for commitment and enhancement of diversity; selection of potential candidates; recruitment;
facilities and resources; training in responsible conduct of research and enhancing reproducibility; support for
career development; and training program evaluations are already existent for this training program. To date,
we have supported 13 PhD or MD/PhD candidates for 1 to 2 years on this training grant; 3 trainees have gone
on to receive their individual NIH F30 or 31 awards, and 3 trainees have graduated and are accepted into
excellent postdoctoral training programs. Our predoctoral program provides exciting and unique opportunities
for study from genomes and proteins to cells, animal models, and humans at the bench and the bedside. The
continuation of this innovative training will undoubtedly produce much needed scientists poised at the frontiers
of both computational and developmental biology.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ethylin Wang Jabs其他文献
Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans
患有黑棘皮病的克鲁宗综合征中的成纤维细胞生长因子受体 3(FGFR3)跨膜突变
- DOI:
10.1038/ng1295-462 - 发表时间:
1995-12-01 - 期刊:
- 影响因子:29.000
- 作者:
Gregory A. Meyers;Seth J. Orlow;Ian R. Munro;Kelly A. Przylepa;Ethylin Wang Jabs - 通讯作者:
Ethylin Wang Jabs
Aural atresia associated with multiple congenital anomalies and mental retardation: A new syndrome
- DOI:
10.1016/s0022-3476(87)80017-3 - 发表时间:
1987-05-01 - 期刊:
- 影响因子:
- 作者:
Linda F. Cooper;Ethylin Wang Jabs - 通讯作者:
Ethylin Wang Jabs
亚洲人群FOXF2基因多核苷酸多态位点与非综合征型唇腭裂关联的新证据
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Bo Zhang;Ethylin Wang Jabs;Alan F. Scott;Terri H. Beaty - 通讯作者:
Terri H. Beaty
国际唇腭裂研究小组数据的基因及基因环境交互作用联合研究关于亚洲人群BMP4基因与非综合征型唇腭裂关联的新证据
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:3.7
- 作者:
Ethylin Wang Jabs;Margaret M. Parker;Alan F. Scott;Terri H. Beaty - 通讯作者:
Terri H. Beaty
A genome wide screen of Crohn's disease in a large pedigree shows evidence for linkages to chromosomes 11, 16, 8 and 15
- DOI:
10.1016/s0016-5085(98)83831-6 - 发表时间:
1998-04-15 - 期刊:
- 影响因子:
- 作者:
Steven R. Brant;Dan Nicolae;Michele C. LaBuda;Romulo Baltazar;Carter Fields;Geoffrey Ravenhill;Mike Pickles;Patrick M. Rohal;Ethylin Wang Jabs;Stephen B. Hanauer;Theodore M. Bayless;Judy H. Cho - 通讯作者:
Judy H. Cho
Ethylin Wang Jabs的其他文献
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{{ truncateString('Ethylin Wang Jabs', 18)}}的其他基金
Cartilage and bone of the lower jaw in development and disease
下颌软骨和骨骼的发育和疾病
- 批准号:
10552606 - 财政年份:2022
- 资助金额:
$ 18.8万 - 项目类别:
Cartilage and bone of the lower jaw in development and disease
下颌软骨和骨骼的发育和疾病
- 批准号:
10357271 - 财政年份:2022
- 资助金额:
$ 18.8万 - 项目类别:
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
下颌面部畸形发生中的遗传、组织和解剖学相互作用
- 批准号:
10220643 - 财政年份:2021
- 资助金额:
$ 18.8万 - 项目类别:
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
下颌面部畸形发生中的遗传、组织和解剖学相互作用
- 批准号:
10663868 - 财政年份:2021
- 资助金额:
$ 18.8万 - 项目类别:
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
下颌面部畸形发生中的遗传、组织和解剖学相互作用
- 批准号:
10470325 - 财政年份:2021
- 资助金额:
$ 18.8万 - 项目类别:
Transcriptome and Network Analysis of Cleft Palate
腭裂的转录组和网络分析
- 批准号:
10539242 - 财政年份:2020
- 资助金额:
$ 18.8万 - 项目类别:
Transcriptome and Network Analysis of Cleft Palate
腭裂的转录组和网络分析
- 批准号:
10314049 - 财政年份:2020
- 资助金额:
$ 18.8万 - 项目类别:
Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
- 批准号:
10159749 - 财政年份:2013
- 资助金额:
$ 18.8万 - 项目类别:
Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
- 批准号:
9260707 - 财政年份:2013
- 资助金额:
$ 18.8万 - 项目类别:
Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
- 批准号:
8640965 - 财政年份:2013
- 资助金额:
$ 18.8万 - 项目类别:
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