Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
基本信息
- 批准号:9906055
- 负责人:
- 金额:$ 19.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
ABSTRACT
Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy
and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular
and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal
development and birth defects are more established classical disciplines. The integration of systems biologic
approaches to the study of normal development and inborn errors of development is emerging. Scientists who
are versed in both mathematics and biology are needed to address the complexities of development biology by
examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and
quantitative manner during the lifetime of an organism. Thus, to promote cross-training in these disciplines, we
are submitting a competitive renewal application to continue the integrated training program, “Interdisciplinary
Training in Systems and Developmental Biology and Birth Defects” at the Icahn School of Medicine at
Mount Sinai in New York City. During the past four years and one month, we successfully built a program that
includes 35 faculty members from 8 different departments, 4 institutes, and 4 multidisciplinary training areas
(Developmental and Regenerative Biology, Neurosciences, Genetics and Genomics Sciences, and Biophysics
and Systems Pharmacology) of the Graduate School of Biological Sciences at Mount Sinai. An outstanding
group of educators and scientists with expertise in systems biology, developmental biology or birth defects,
including the Directors and members of the External Advisory, Executive Faculty, and Curriculum Committees,
provide the leadership, administration, and mentorship for the program. The Curriculum emphasizes the
integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology,
biochemistry, physiology, pharmacology, quantitative reasoning, computational biology, and bioinformatics. We
have created novel courses, journal clubs, and seminar series combining principles of systems biology,
developmental biology and birth defects in order to enhance the unique learning experience. The institutional
infrastructure for commitment and enhancement of diversity; selection of potential candidates; recruitment;
facilities and resources; training in responsible conduct of research and enhancing reproducibility; support for
career development; and training program evaluations are already existent for this training program. To date,
we have supported 13 PhD or MD/PhD candidates for 1 to 2 years on this training grant; 3 trainees have gone
on to receive their individual NIH F30 or 31 awards, and 3 trainees have graduated and are accepted into
excellent postdoctoral training programs. Our predoctoral program provides exciting and unique opportunities
for study from genomes and proteins to cells, animal models, and humans at the bench and the bedside. The
continuation of this innovative training will undoubtedly produce much needed scientists poised at the frontiers
of both computational and developmental biology.
摘要
系统生物学是一门相对较新的学科,用于理解健康背后的复杂相互作用。
细胞、组织或有机体的疾病状态,需要过程和分子网络的知识
以及细胞、器官和整个有机体内部和之间的蛋白质相互作用。正态分布的研究
发育和出生缺陷是更成熟的经典学科。系统生物学的整合
研究正常发育和先天发育错误的方法正在出现。科学家们
精通数学和生物学,通过以下方式解决发育生物学的复杂性
考察在时间空间和时间空间中同时发生的数千到数百万个因素和事件
在有机体的生命周期中以定量的方式。因此,为了促进这些学科的交叉培训,我们
正在提交竞争续签申请,以继续实施综合培训计划
伊坎医学院系统和发育生物学与出生缺陷方面的培训
纽约市的西奈山。在过去的四年零一个月里,我们成功地建立了一个项目,
包括来自8个不同系、4个研究所和4个多学科培训领域的35名教职员工
发育与再生生物学、神经科学、遗传学与基因组学、生物物理学
和系统药理学),西奈山生物科学研究院。一位杰出的
一群在系统生物学、发育生物学或出生缺陷方面有专长的教育工作者和科学家,
包括外部咨询、行政学院和课程委员会的主任和成员,
为项目提供领导、管理和指导。《课程》强调
综合了发育生物学、先天发育错误、基因组学、分子生物学、
生物化学、生理学、药理学、定量推理、计算生物学和生物信息学。我们
创建了新颖的课程、期刊俱乐部和结合系统生物学原理的系列研讨会,
发育生物学和出生缺陷,以提升独特的学习体验。体制上的
承诺和加强多样性的基础设施;挑选潜在候选人;征聘;
设施和资源;负责任地进行研究和提高可再现性的培训;支持
该培训方案已经存在职业发展和培训方案评估。到目前为止,
我们已经用这笔培训补助金资助了13名博士生或医学博士/博士生1到2年;3名学员已经离开
获得个人NIH F30或31奖项,3名学员已毕业并被录取
优秀的博士后培训计划。我们的博士前项目提供了令人兴奋和独特的机会
用于研究从基因组和蛋白质到细胞、动物模型,以及长凳和床边的人类。这个
这种创新培训的继续无疑将培养出急需的、站在前沿的科学家。
计算生物学和发育生物学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ethylin Wang Jabs其他文献
Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans
患有黑棘皮病的克鲁宗综合征中的成纤维细胞生长因子受体 3(FGFR3)跨膜突变
- DOI:
10.1038/ng1295-462 - 发表时间:
1995-12-01 - 期刊:
- 影响因子:29.000
- 作者:
Gregory A. Meyers;Seth J. Orlow;Ian R. Munro;Kelly A. Przylepa;Ethylin Wang Jabs - 通讯作者:
Ethylin Wang Jabs
Aural atresia associated with multiple congenital anomalies and mental retardation: A new syndrome
- DOI:
10.1016/s0022-3476(87)80017-3 - 发表时间:
1987-05-01 - 期刊:
- 影响因子:
- 作者:
Linda F. Cooper;Ethylin Wang Jabs - 通讯作者:
Ethylin Wang Jabs
亚洲人群FOXF2基因多核苷酸多态位点与非综合征型唇腭裂关联的新证据
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Bo Zhang;Ethylin Wang Jabs;Alan F. Scott;Terri H. Beaty - 通讯作者:
Terri H. Beaty
国际唇腭裂研究小组数据的基因及基因环境交互作用联合研究关于亚洲人群BMP4基因与非综合征型唇腭裂关联的新证据
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:3.7
- 作者:
Ethylin Wang Jabs;Margaret M. Parker;Alan F. Scott;Terri H. Beaty - 通讯作者:
Terri H. Beaty
A genome wide screen of Crohn's disease in a large pedigree shows evidence for linkages to chromosomes 11, 16, 8 and 15
- DOI:
10.1016/s0016-5085(98)83831-6 - 发表时间:
1998-04-15 - 期刊:
- 影响因子:
- 作者:
Steven R. Brant;Dan Nicolae;Michele C. LaBuda;Romulo Baltazar;Carter Fields;Geoffrey Ravenhill;Mike Pickles;Patrick M. Rohal;Ethylin Wang Jabs;Stephen B. Hanauer;Theodore M. Bayless;Judy H. Cho - 通讯作者:
Judy H. Cho
Ethylin Wang Jabs的其他文献
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{{ truncateString('Ethylin Wang Jabs', 18)}}的其他基金
Cartilage and bone of the lower jaw in development and disease
下颌软骨和骨骼的发育和疾病
- 批准号:
10552606 - 财政年份:2022
- 资助金额:
$ 19.02万 - 项目类别:
Cartilage and bone of the lower jaw in development and disease
下颌软骨和骨骼的发育和疾病
- 批准号:
10357271 - 财政年份:2022
- 资助金额:
$ 19.02万 - 项目类别:
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
下颌面部畸形发生中的遗传、组织和解剖学相互作用
- 批准号:
10220643 - 财政年份:2021
- 资助金额:
$ 19.02万 - 项目类别:
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
下颌面部畸形发生中的遗传、组织和解剖学相互作用
- 批准号:
10663868 - 财政年份:2021
- 资助金额:
$ 19.02万 - 项目类别:
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
下颌面部畸形发生中的遗传、组织和解剖学相互作用
- 批准号:
10470325 - 财政年份:2021
- 资助金额:
$ 19.02万 - 项目类别:
Transcriptome and Network Analysis of Cleft Palate
腭裂的转录组和网络分析
- 批准号:
10539242 - 财政年份:2020
- 资助金额:
$ 19.02万 - 项目类别:
Transcriptome and Network Analysis of Cleft Palate
腭裂的转录组和网络分析
- 批准号:
10314049 - 财政年份:2020
- 资助金额:
$ 19.02万 - 项目类别:
Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
- 批准号:
10159749 - 财政年份:2013
- 资助金额:
$ 19.02万 - 项目类别:
Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
- 批准号:
9260707 - 财政年份:2013
- 资助金额:
$ 19.02万 - 项目类别:
Interdisciplinary Training in Systems and Developmental Biology and Birth Defects
系统与发育生物学和出生缺陷的跨学科培训
- 批准号:
8640965 - 财政年份:2013
- 资助金额:
$ 19.02万 - 项目类别:
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