STRUCTURAL FUNCTIONAL RELATIONSHIPS IN DIABETIC NEPHROPATHY

糖尿病肾病的结构功能关系

• 批准号: 7375850
• 负责人: MICHAEL S MAUER
• 金额: $ 1.76万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375850
• 关键词: STRUCTURAL; FUNCTIONAL; RELATIONSHIPS; DIABETIC; NEPHROPATHY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol has two major purposes. First, we are examining structural-functional relationships in diabetic nephropathy using quantitative light and electron microscopic morphometry to determine the structural substrates for microalbuminuria, proteinuria, hypertension and declining GFR. Secondly, we are examining the effects of pancreas transplant on the established lesions of diabetic nephropathy at five, ten, and fifteen year intervals after successful transplantation.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该协议有两个主要目的。首先，我们正在研究糖尿病肾病的结构-功能关系，使用定量光和电子显微镜形态计量学来确定微量蛋白尿、蛋白尿、高血压和GFR下降的结构底物。其次，我们正在研究胰腺移植在成功移植后五年、十年和十五年对糖尿病肾病已建立的病变的影响。