BEYOND RASS STUDY (B-RASS)-AN EXTENSION OF RENIN ANGIOTENSIN SYSTEM STUDY (RASS)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。具体目标1：跟踪285名1型糖尿病患者完成为期5年的RASS的队列，其中三分之一服用ACEI，三分之一服用ARB，三分之一服用安慰剂，再观察10年，每年测量白蛋白排泄率(AER)、血压(BP)和每两年测量一次肾小球滤过率(GFR)。具体目标2：跟踪285例1型糖尿病患者完成为期5年的RASS的队列，并进行3次眼底照片的间隔评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: To follow the cohort of 285 patients with type 1 DM completing the 5-year RASS, one-third of whom were on ACEi, one-third on ARB, and one-third on placebo, for a further 10 years with annual measurements of albumin excretion rate (AER), blood pressure (BP) and bi-annual measurement of glomerular filtration rate (GFR). Specific Aim 2: To follow the cohort of 285 patients with type 1 DM completing the 5-year RASS for a further 10 years with 3 interval assessments of fundus photographs.