CEREBRAL RESPONSES TO INSULIN-INDUCED HYPOGLYCEMIA-AIMS 1 & 2

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to determine the blood and brain glucose concentrations at which regional cerebral blood flow is increased during hypoglycemia in normal subjects, subjects with poorly controlled diabetes, and those with hypoglycemia unawareness. In this experiment we will examine cerebral blood flow as measured by NMR under conditions in which serum glucose levels are suppressed during a hypoglycemic clamp. The role of the GCRC will be to assist with hypoglycemic clamp at the magnet center and to provide subjects with a meal at the completion of the study.