WHITE MATTER STRUCTURE/FUNCTION IN DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的长期目标是确定糖尿病的影响以及强化治疗对人类体内脑代谢和功能的降糖后果，以确定糖尿病患者是否发生脑白质微结构变化。在目前的实验中，我们打算测试一种假设，即长期存在的1型糖尿病患者的各向异性分数比性别和年龄匹配的健康志愿者要低，这种骨折各向异性的减少将与神经认知功能的异常相关。为了确定合适的样本量来解决这一假设，我们现在提议进行一个试点项目，将5名1型糖尿病患者与5名年龄和性别匹配的对照组进行比较。这项建议的具体目的是收集支持NIH申请的试点数据，目的是确定长期患有1型糖尿病的受试者是否存在脑白质结构异常，这些结构异常可以通过3特斯拉的扩散张量成像检测到，并与神经认知功能异常相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain metabolism and function in humans to determine whether white matter microstructural changes occur in patients with diabetes. In the current experiment we intend to test the hypothesis that patients with long standing type 1 diabetes will have lower measures of fractional anisotropy than will healthy volunteers matched for gender and age and this reduction in fractoinal anisotropy will correlate with abnormalties in neurocognitive function. To determine the appropriate sample size to study to address this hypothesis, we now propose to perform a pilot project in which five subjects with type 1 diabetes are compared to five age and gender matched control subjects. The specific aim of this proposal is to collect pilot data that will support a NIH application with the aim of determining whether the subjects with long standing type 1 diabetes mellitus have structural abnormalities in white matter that can be detected by diffusion tensor imaging at 3 Tesla and correlated with abnormalites in neurocognitive function.