WHITE MATTER STRUCTURE/FUNCTION IN DIABETES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-range goal of this project is to determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain metabolism and function in humans to determine whether white matter microstructural changes occur in patients with diabetes. In the current experiment we intend to test the hypothesis that patients with long standing type 1 diabetes will have lower measures of fractional anisotropy than will healthy volunteers matched for gender and age and this reduction in fractoinal anisotropy will correlate with abnormalties in neurocognitive function. To determine the appropriate sample size to study to address this hypothesis, we now propose to perform a pilot project in which five subjects with type 1 diabetes are compared to five age and gender matched control subjects. The specific aim of this proposal is to collect pilot data that will support a NIH application with the aim of determining whether the subjects with long standing type 1 diabetes mellitus have structural abnormalities in white matter that can be detected by diffusion tensor imaging at 3 Tesla and correlated with abnormalites in neurocognitive function.